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Your Position: Home > TME Relevant Pathway > Integrin alpha M beta 2 > IT2-R52E2

Rat Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer Protein, His Tag&Tag Free

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  • Synonym
    Integrin alpha M beta 2,ITGAM&ITGB2
  • Source
    Rat Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer, His Tag&Tag Free(IT2-R52E2) is expressed from human 293 cells (HEK293). It contains AA Phe 17 - Pro 1104 (ITGAM) & Glu 23 - Asn 699 (ITGB2) (Accession # G3V8L7-1 (ITGAM) & NP_001032869.2 (ITGB2)).
    Predicted N-terminus: Phe 17 | Gln 23
  • Molecular Characterization
    Integrin alpha M beta 2 Structure

    The protein has a calculated MW of 127 kDa | 80 kDa.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $410.00

Price(USD) : $2880.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Discontinued

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