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Your Position: Home > TME Relevant Pathway > Integrin alpha 3 beta 1 > IT1-R52Wb

Rat ITGA3 & ITGB1 Heterodimer Protein, His Tag&Tag Free

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  • Synonym
    Integrin alpha 3 beta 1,ITGA3&ITGB1
  • Source
    Rat ITGA3 & ITGB1 Heterodimer, His Tag&Tag Free(IT1-R52Wb) is expressed from human 293 cells (HEK293). It contains AA Phe 38 - Pro 1034 (ITGA3) & Gln 21 - Asp 729 (ITGB1) (Accession # I4DUB5 (ITGA3) & P49134 (ITGB1)).
    Predicted N-terminus: Phe 38 | Gln 21
  • Molecular Characterization

    Rat ITGA3 & ITGB1 Heterodimer Protein, His Tag&Tag Free, has a calculated MW of 117.2 kDa (ITGA3) & 83.7 kDa (ITGB1). Subunit ITGA3 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.

  • Endotoxin
    Less than 0.01 EU per μg by the LAL method.
  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $410.00

Price(USD) : $2880.00

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Drug Development Status

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  • Number of Drugs in Clinical Trials:1 Details
  • Latest Research Phase:Phase 1 Clinical

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