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Your Position: Home > Other Recombinant Proteins > Human ROBO4 ECSM4 Protein

Human ROBO4 Protein

  • Synonym
    ROBO4,ECSM4,MRB
  • Source
    Human ROBO4, His Tag (RO4-H5224) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Glu 469 (Accession # AAI11563).
    Predicted N-terminus: Gln 28
  • Molecular Characterization
    ROBO4(Gln 28 - Glu 469) AAI11563

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 48.5 kDa. The protein migrates as 55-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human ROBO4, His Tag (Cat. No. RO4-H5224) SDS-PAGE gel

Human ROBO4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Roundabout homolog 4 (ROBO4) is also known as Magic roundabout (MRB) and ECSM4, which belongs to the immunoglobulin superfamily or ROBO family. ROBO4 contains 2 fibronectin type-III domains and 2 Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is specifically expressed in endothelial cells and is also expressed at sites of angiogenesis in different tumor types. ROBO4 / MRB is the receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO-4 may mediate the inhibition of primary endothelial cell migration by Slit proteins.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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