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Your Position: Home > Protein > OX40 Ligand > OXL-C5243

Cynomolgus/Rhesus macaque OX40 Ligand Protein, His Tag (active trimer) (MALS verified)

  • Synonym
    OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L
  • Source
    Cynomolgus/Rhesus macaque OX40 Ligand, His Tag (OXL-C5243) is expressed from human 293 cells (HEK293). It contains AA Gln 51 - Leu 183 (Accession # A0A1D5QQH7 ).
    Predicted N-terminus: His
  • Molecular Characterization

    This protein carries a polyhistidine tag at the N-terminus

    The protein has a calculated MW of 49.3 kDa. The protein migrates as 65-80 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
OX40 Ligand SDS-PAGE

Cynomolgus/Rhesus macaque OX40 Ligand, His Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
OX40 Ligand MALS images

The purity of Cynomolgus/Rhesus macaque OX40 Ligand, His Tag (Cat. No. OXL-C5243) is more than 95% and the molecular weight of this protein is around 60-70 kDa verified by SEC-MALS.

Bioactivity-ELISA
 OX40 Ligand ELISA

Immobilized Cynomolgus/Rhesus macaque OX40 Ligand, His Tag (Cat. No. OXL-C5243) at 2 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque OX40, Fc Tag (Cat. No. OX0-C5251) with a linear range of 0.1-3 ng/mL (QC tested).

 OX40 Ligand ELISA

Immobilized Cynomolgus/Rhesus macaque OX40 Ligand, His Tag (Cat. No. OXL-C5243) at 2 μg/mL (100 μL/well) can bind Human OX40, Fc Tag (Cat. No. OX0-H5255) with a linear range of 0.1-1 ng/mL (Routinely tested).

 OX40 Ligand ELISA

Immobilized Cynomolgus / Rhesus macaque OX40, Fc Tag (Cat. No. OX0-C5251) at 5 μg/mL (100 μL/well) can bind Cynomolgus/Rhesus macaque OX40 Ligand, His Tag (Cat. No. OXL-C5243) with a linear range of 20-78 ng/mL (Routinely tested).

  • Background
    Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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ETD of in-stock products: 2 business days

Price(USD) : $350.00

Price(USD) : $2310.00

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