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Your Position: Home > Protein > BTN2A2 > BT2-H5258

Human BTN2A2 Protein, Fc Tag

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  • Synonym
  • Source
    Human BTN2A2 Protein, Fc Tag(BT2-H5258) is expressed from human 293 cells (HEK293). It contains AA Gln 33 - Met 265 (Accession # Q8WVV5-1 ).
    Predicted N-terminus: Gln 33
  • Molecular Characterization
    BTN2A2 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus

    The protein has a calculated MW of 52.6 kDa.

  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Recently, several members of the BTN /BTNL superfamily have been implicated in T cell response. BTN2A2 (butyrophilin 2a2), co-stimulatory molecule first discovered in APC cells, plays an important role in maintaining T cell homeostasis. Btn1a1 and Btn2a2 have been shown to inhibit T cell activity in mice, and secreted soluble Btn2a2 has been found to inhibit the proliferation of activated CD4 and CD8T cells and reduce T cell receptor signaling by reducing Zap70, CD3E and ERK phosphorylation. As a cell surface protein, Btn2a2 can be expressed in CD19+B cells, CD11c+ spleen DC cells and CD11b+Ly6Glow peritoneal macrophages.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $350.00

Price(USD) : $2310.00

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