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Your Position: Home > Protein > HLA-A*0301 & B2M & KRASG12C (VVGACGVGK) > HLC-H52H7

Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Tetramer Protein

This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
  • Source
    Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Tetramer Protein(HLC-H52H7) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Thr 305 (HLA-A*03:01) & Ile 21 - Met 119 (B2M) & VVGACGVGK peptide (Accession # P04439 (HLA-A*03:01) & P61769 (B2M) & VVGACGVGK).
    Predicted N-terminus: Gly 25 & Ile 21
  • Molecular Characterization

    Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Tetramer Protein is assembled by biotinylated monomer and streptavidin.

    Biotinylated Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Complex Protein is produced by co-expression of HLA and B2M loaded with KRASG12C peptide. Biotinylated Human HLA-A*03:01&B2M&KRASG12C (VVGACGVGK) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 36.0 kDa and 11.7 kDa.

  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    The Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) oncogene plays a critical role in the initiation and maintenance of pancreatic tumors and its signaling network represents a major target for therapeutic intervention. The Biotinylated Human HLA-A*0301 KRASG12C (VVGACGVGK) complex protein is a complex of HLA-A*0301 of the MHC Class I, B2M, and VVGACGVGK peptide of the KRASG12C.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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