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Your Position: Home > All Other Proteins > IL-2 R beta > Human IL2RB CD122 Protein With C-Fc Tag

Human IL-2 R beta / CD122 Protein, Fc Tag

  • Synonym
    IL2RB,RP5-1170K4.6,CD122,P70-75
  • Source
    Human IL-2 R beta, Fc Tag (ILB-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Asp 239 (Accession # NP_000869.1).
    Predicted N-terminus: Ala 27
  • Molecular Characterization
    IL-2 R beta(Ala 27 - Asp 239) NP_000869.1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 50.7 kDa. The protein migrates as 58-76 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;

    2. -70°C for 3 months under sterile conditions after reconstitution.

SDS-PAGE
Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) SDS-PAGE gel

Human IL-2 R beta, Fc Tag on SDS-PAGE  under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

Bioactivity
Human IL-2 R beta, Fc TagHuman IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) ELISA bioactivity

Immobilized Human IL-15, Tag Free (Cat. No. IL5-H4217) at 10 μg/mL (100 μL/well) can bind Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) with a linear range of 0.156-2.5 μg/mL (QC tested).

Human IL-2 R beta, Fc TagHuman IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) ELISA bioactivity

Immobilized Human IL-2 R beta, Fc Tag (Cat. No. ILB-H5253) at 2 μg/mL (100 μL/well) can bind Human IL-2, Tag Free (Cat. No. IL2-H4216) with a linear range of 0.156-2.5 μg/mL (Routinely tested).

  • Background
    Interleukin-2 receptor subunit beta (IL2RB) is also known as CD122, which Belongs to the type I cytokine receptor family. Type 4 subfamily. IL2RB contains 1 fibronectin type-III domain. IL2RB / CD122 is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $350.00

Price(USD) : $2600.00

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