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Matrigengel Matrix (Acro Certified)

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    Matrigengel PRODUCT SHOW

  • Key Benefits

    1. Cellular Function Assay Validated - Strict Quality Control Assays for every produced lot.
    2. Lot-to-lot Consistency - Strict manufacturing controls and management systems.
    3. Stable, Long-term Supply - Large-scale manufacturing capacity and ACRO’s global supply chain.
    4. Cost Effective - Bulk pricing available to meet your research needs.

  • Intended Use
    Matrigengel Matrix is intended to be used in 2D or 3D cultures related to cell proliferation, cell differentiation, cell invasion, angiogenesis, or organoid culture, among many other applications.
  • Product Description
    1. Basement membranes are comprised of continuous sheets of a specialized extracellular matrix. It acts an interface between various types of cells, including muscle, neuronal, epithelial, or endothelial cells, along with adjacent stroma. Basement membranes are an essential part in the organization of tissues forming the scaffolding and support for cellular growth and cell layers. They also affect a variety of cellular mechanisms such as adhesion, migration, proliferation, and differentiation. Basement membranes are selectively degraded and regenerated during development and wound healing, forming the base scaffold for tissue reconstruction. Basement membranes also act as a major barrier to invasion by metastatic tumor cells.
    2. Matrigengel Matrix is a soluble form of basement membrane that is purified from gene-edited mouse tumor cells grown in LDEV-free mouse populations. Reconstitution into the original basement membrane form occurs at 37℃ and is mainly comprised of laminin, collagen IV, entactin, and heparin sulfate proteoglycan.
Bioactivity-Angiogenesis Assay

The complete medium and HUVECs suspension (2×10^4/well in 96 wells) can form the excellent tubular structure on 100% and 67% Matrigengel Matrix (Cat. No. AC-M082704) at 4 hours, which can be quickly performed for subsequent staining and angiogenesis analysis.

Bioactivity-Tumor Invasion Assay

The invasion effect of 5×10^4 SGC-7901 was detected for 24 hours at different concentrations of Matrigengel (Cat. No. AC-M082704) and it was clear that the number of successfully invaded cells decreased significantly as the concentration of matrigel increased.

Protein ConcentrationWithin 8 to 13 mg/mL, tested by BCA assay.
Endotoxin Level< 4.5 EU/mL, tested by LAL assay.
Tumor InvasionCells pass through basement membrane matrix and into the lower compartment, tested by Tumor invasion. Tumor cells can also be cultured on the basement membrane matrix.
*Evaluated Matrigengel Matrix: Medium Ratio = 1:4, 1:6, 1:8 (v/v).
AngiogenesisBlood vessel formation is observed, tested by HUVEC angiogenesis assay.
*Evaluated Matrigengel Matrix: Medium Ratio = 1:0 (original formulation), 2:1, 1:1 (v/v).
SterilityNo growth observed after 14 days. Testing for the detection of bacteria, fungi, and mycoplasma through cell culture.
Viral TestingTested negative by ELISA, bacterial culture and microscope observation for a total of 19 bacterial and virus strains, and additional murine infectious agents including LDEV.
StabilityProduct is stable for at least two years from date of manufacture when stored at ≤ -20℃. See lot specific Certificate of Analysis for expiration date.
Shipping ConditionsThe product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
StorageStore at -20℃. Avoid multiple freeze-thaws. Do not store in frost-free freezer. KEEP FROZEN.
Acro Certify Disclaimer
This product is one of ACROBiosystems' Certify products. ACROBiosystems and our Certify partners have established a close partnership that includes an in-depth review of quality management and quality audits this product. Products from our Certify partners have been qualified by ACROBiosystems to be included under Acro Certify. ACROBiosystems may provide Product information, including technical information, specifications, recommendations, literature, and other material (collectively, "Product Information") for customer's convenience. The accuracy and completeness of Product Information is not guaranteed and is subject to change without notice. ACROBiosystems is not responsible for the intellectual property or impact to intellectual property for products sold under Acro Certify.

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