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Your Position: Home > Protein > Argonaute-2 > AR2-H5543

Human Argonaute-2 Protein, His Tag

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  • Synonym
    CASC7, EIF2C2, LESKRES, LINC00980, PPD, Q10
  • Source
    Human Argonaute-2 Protein, His Tag(AR2-H5543) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 859 (Accession # Q9UKV8-1 ).
    Predicted N-terminus: His
  • Molecular Characterization
    Argonaute-2 Structure

    This protein carries a polyhistidine tag at the N-terminus

    The protein has a calculated MW of 99.1 kDa .

  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    The Argonaute (AGO) family proteins are defined by the presence of Piwi-Argonaute-Zwille (PAZ)) and PIWI domains 2, and mediate silencing via cleavage of mRs 3 or inhibition of translation 4. The AGO family proteins fall into two subfamilies, one named after Arabidopsis Argonaute and the other after Drosophila PIWI 5. In most organisms investigated so far, PIWI proteins bind Piwi-interacting Rs (piRs) and are functionally involved in the regulation of germ cells 6, 7. By contrast, AGO proteins have distinct roles in the small-R-mediated gene silencing pathway.
    Argonaute-2 (Ago2) is a key component of the R-induced silencing complex (RISC) that mediates downregulation of mR by microRs. Its presence in extracellular vesicles (EVs) has been postulated to be important for the activity of EV-carried miR in modulating gene expression in recipient cells.
  • Clinical and Translational Updates
  • Please contact us via if you have any question on this product.

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Price(USD) : $420.00

Price(USD) : $2730.00

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