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Your Position: Home > Protein > Envelope protein > ENN-D5243

DENV2 (strain Thailand/16681/1984) Envelope Protein, His Tag (MALS & SPR verified)

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  • Synonym
    Envelope protein,Env polyprotein,Envelope glycoprotein,env
  • Source
    DENV2 (strain Thailand/16681/1984) Envelope Protein, His Tag(ENN-D5243) is expressed from human 293 cells (HEK293). It contains AA Phe 115 - Thr 280 & Met 281 - Ser 677 (Accession # P29990 ).
  • Molecular Characterization

    This protein carries a polyhistidine tag at the N-terminus

    The protein has a calculated MW of 65.0 kDa. The protein migrates as 60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Envelope protein SDS-PAGE

DENV2 (strain Thailand/16681/1984) Envelope Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Envelope protein MALS images

The purity of DENV2 (strain Thailand/16681/1984) Envelope Protein, His Tag (Cat. No. ENN-D5243) is more than 90% and the molecular weight of this protein is around 60-80 kDa verified by SEC-MALS.

 Envelope protein SPR

Anti-E(DENV) Antibody EDE2 A11 captured on Protein G-Series S sensor chip can bind DENV2 (strain Thailand/16681/1984) Envelope Protein, His Tag (Cat. No. ENN-D5243) with an affinity constant of 58.4 nM as determined in a SPR assay (Biacore 8K) (QC tested).

  • Background
    Dengue is a mosquito-borne viral disease widely spread all over the world transmitted by 4 serotypes of dengue virus (DENV). The symptoms range from mild dengue fever to dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) with high mortality. Currently, most of the studies on DENV vaccines emphasize on its envelope protein which is essential for viral attachment and fusion (i.e., Sanofi’s tetravalent dengue vaccine Dengvaxia). However, the vaccine of envelope protein still needs to be improved to maximize its efficiency on people never infected with DENV before, which requires more research to be conducted on the DENV envelope protein.
  • Clinical and Translational Updates
  • Please contact us via if you have any question on this product.

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  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Approved

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