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Your Position: Home > Protein > Laminin 211 E8 > LA8-H5263

Human Laminin 211 E8 Protein, Fc Tag (HPLC verified)

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  • Synonym
    Laminin 211 E8
  • Source
    Human Laminin 211 E8 Protein, Fc Tag(LA8-H5263) is expressed from human 293 cells (HEK293). It contains AA Leu 1900 - Ala 2722 & Asp 1714 - Leu 1786 & Asp 1528 - Pro 1609 (Accession # P24043 & P07942 & P11047 ).
    Predicted N-terminus: Leu 1900 & Pro & Pro
  • Molecular Characterization

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 94.3 kDa & 35 kDa & 35.7 kDa. The protein migrates as 70-80 Da and 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Laminin 211 E8 SDS-PAGE

Human Laminin 211 E8 Protein, Fc Tag on SDS-PAGE under non-reducing (NR) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Laminin 211 E8 SEC-HPLC

The purity of Human Laminin 211 E8 Protein, Fc Tag (Cat. No. LA8-H5263) was greater than 85% as determined by SEC-HPLC.

 Laminin 211 E8 ELISA

Immobilized Human Laminin 211 E8 Protein, Fc Tag (Cat. No. LA8-H5263) at 5 μg/mL (100 μL/well) can bind Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W8) with a linear range of 0.02-0.313 μg/mL (QC tested).

  • Background
    Laminin-α2 is a critical component of the laminin heterotrimer, which along with laminin-β1 or β2 and laminin-γ1 form the structural glycoproteins laminin-211 and laminin-221 in skeletal muscle. Laminin-211 is the most abundant laminin isoform in the basement membrane of adult skeletal muscle. Laminin-211 and -221 polymerize with each other and interact with nidogen and collagen-IV to form the muscle basal lamina. Laminin-211 and laminin-221 bind to muscle cell surface through the α7β1 integrin and α-dystroglycan of the dystrophin glycoprotein complex via their globular C-terminal domains.
  • Clinical and Translational Updates
  • Please contact us via if you have any question on this product.

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