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Your Position: Home > Bio-Markers & CD Antigens > Human PROCR /EPCR /CD201 Protein

Human PROCR / EPCR / CD201 Protein

  • Synonym
    PROCR,EPCR,CD201,APC receptor,CCCA,CCD41
  • Source
    Human PROCR, His Tag (PRR-H5223) is expressed from human 293 cells (HEK293). It contains AA Ser 18 - Thr 209 (Accession # AAH14451).
    Predicted N-terminus: Ser 18
  • Molecular Characterization
    PROCR(Ser 18 -  Thr 209) AAH14451

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 22.8 kDa. The protein migrates as 33-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human PROCR, His Tag (Cat. No. PRR-H5223) SDS-PAGE gel

Human PROCR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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