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Your Position: Home > All Other Proteins > TWEAK R > Human TNFRSF12A /FN14 Protein,N-Fc Tag,HEK293 expressed

Human TWEAK R / TNFRSF12 Protein, Fc Tag

  • Synonym
    TNFRSF12A,FGF-inducible 14,FN14,TweakR,CD266
  • Source
    Human TWEAK R, Fc Tag (TNA-H526a) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Trp 79 (Accession # AAH02718).
    Predicted N-terminus: Gly
  • Molecular Characterization
    TWEAK R(Glu 28 - Trp 79) AAH02718

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 33 kDa. As a result of glycosylation, the protein migrates as 32-40 kDa under reducing (R) condition, and 65-80 kDa under non-reducing (NR) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss was observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human TWEAK R, Fc Tag (Cat. No. TNA-H526a) SDS-PAGE gel

Human TWEAK R, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14 (FN14 or FGF-inducible 14), Tweak-receptor, CD antigen CD266. TNFRSF12A contains one TNFR-Cys repeat. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A is receptor for TNFSF12/TWEAK, and is weak inducer of apoptosis in some cell types. TNFRSF12A / FN14 promotes angiogenesis and the proliferation of endothelial cells.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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