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Your Position: Home > Recombinant Proteins > Fc epsilon RI alpha > Human FCER1A /FCE1A Protein

Human Fc epsilon RI alpha Protein

  • Synonym
  • Source
    Human Fc epsilon RI alpha, His Tag (FCA-H5228) is expressed from human 293 cells (HEK293). It contains AA Val 26 - Gln 205 (Accession # P12319-1).
    Predicted N-terminus: Val 26
  • Molecular Characterization
    FCER1A(Val 26 - Gln 205) P12319-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 22.9 kDa. The protein migrates as 37-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human Fc epsilon RI alpha, His Tag (Cat. No. FCA-H5228) SDS-PAGE gel

Human Fc epsilon RI alpha, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Human Fc epsilon RI alpha, His TagHuman Fc epsilon RI alpha, His Tag (Cat. No. FCA-H5228) ELISA bioactivity

Immobilized Immunoglobulin E, Human Plasma at 5 μg/mL (100 μL/well) can bind Human FCER1A, His Tag (Cat. No. FCA-H5228) with a linear range of 0.4-3 ng/mL (QC tested).

  • Background
    High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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