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Your Position: Home > Protein > SLC7A11 & SLC3A2 > SLS-H52D3

Human SLC7A11&SLC3A2 Full Length Protein, Flag,His Tag (Detergent)

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  • Source
    Human SLC7A11&SLC3A2 Full Length Protein, Flag,His Tag(SLS-H52D3) is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 501 & Glu 2- Ala 630 (Accession # Q9UPY5 & P08195).
    Predicted N-terminus: Met & Met
  • Molecular Characterization

    The protein has a calculated MW of 59.4 kDa & 69.9 kDa.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Formulation

    This product is not suitable for cell based experiments due to cytotoxicity of DDM.
    DDM and CHS are INDISPENSABLE to keep membrane protein soluble and active, under no circumastance should you remove DDM and CHS.
    DDM/CHS buffer (DC-11) is sold separately and not included in protein, and please contact us if you need the buffer.
    If glycerol is not compatible to your application, remove glycerol just before immediate experiment, and NEVER store glycerol-free protein solution.

    Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
**The DDM/CHS buffer (Cat. No. DC-11) is sold separately and not included in protein, you can follow this link for product information.
Bioactivity-ELISA
 SLC7A11 & SLC3A2 ELISA

Immobilized Human SLC7A11&SLC3A2 Full Length Protein, Flag,His Tag (Cat. No. SLS-H52D3) at 5 μg/mL (100 μL/well) can bind Anti-SLC7A11 Antibody with a linear range of 2-63 ng/mL (QC tested).

Bioactivity-SPR
 SLC7A11 & SLC3A2 SPR

SLC7A11 Antibody captured on Protein A Chip can bind Human SLC7A11&SLC3A2 Full Length Protein, Flag,His Tag (Cat. SLS-H52D3) with an affinity constant of 21.7 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested).

  • Background
    Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability of cysteine. However, circulating cysteine exists in the blood as the oxidised di-peptide cystine, requiring specialised transport systems for its import into the cell. System xc- is a dedicated cystine transporter, importing cystine in exchange for intracellular glutamate. To counteract elevated levels of reactive oxygen species in cancerous cells system xc- is frequently upregulated, making it an attractive target for anticancer therapies.
  • Clinical and Translational Updates

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