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Your Position: Home > Protein > LRRC15 > LR5-H51H3

Human LRRC15 / LIB Protein, His Tag (MALS verified)

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  • Synonym
    Leucine-rich repeat-containing protein 15,LRRC15,LIB,hLib
  • Source
    Human LRRC15 Protein, His Tag(LR5-H51H3) is expressed from CHO cells. It contains AA Tyr 22 - Gly 538 (Accession # Q8TF66-1).
    Predicted N-terminus: Tyr 22
  • Molecular Characterization
    LRRC15 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 59.7 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
LRRC15 SDS-PAGE

Human LRRC15 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
LRRC15 MALS images

The purity of Human LRRC15 Protein, His Tag (Cat. No. LR5-H51H3) is more than 90% and the molecular weight of this protein is around 55-85 kDa verified by SEC-MALS.

Bioactivity-ELISA
 LRRC15 ELISA

Immobilized Human LRRC15 Protein, His Tag (Cat. No. LR5-H51H3) at 2 μg/mL (100 μL/well) can bind Samrotamab with a linear range of 0.4-6 ng/mL (QC tested).

  • Background
    LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.
  • Clinical and Translational Updates

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