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Your Position: Home > Bio-Markers & CD Antigens > Neuropilin-1 > Human NRP1 /Neuropilin‑1 /CD304 Protein

Human Neuropilin-1 / NRP1 / CD304 Protein

  • Synonym
  • Source
    Human Neuropilin-1, His Tag (NR1-H5228) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Lys 644 (Accession # AAH07533).
    Predicted N-terminus: Phe 22
  • Molecular Characterization
    NRP1(Phe 22 - Lys 644) AAH07533

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 70.7 kDa. The protein migrates as 85-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human Neuropilin-1, His Tag (Cat. No. NR1-H5228) SDS-PAGE gel

Human Neuropilin-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

Human Neuropilin-1, His TagHuman Neuropilin-1, His Tag (Cat. No. NR1-H5228) ELISA bioactivity

Immobilized Human NRP1, His Tag (Cat. No. NR1-H5228) at 2 μg/mL (100 μL/well) can bind Biotinylated Human VEGF165, Tag Free (Cat. No. VE5-H8210) with a linear range of 1-8 ng/mL (QC tested).

  • Background
    Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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