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Your Position: Home > Antibody > C11D5.3 scFv > C13-PCFMY2

PE-Labeled Monoclonal Anti-C11D5.3 scFv Antibody, Mouse IgG1 (3G8C1) (0.03% Proclin)

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  • Source
    Monoclonal Anti-C11D5.3 scFv Antibody, Mouse IgG1 (3G8C1) is expressed from human HEK293 cells, which provides higher batch consistency and long term security of supply.
  • Application
    Flow Cytometry (Evaluation of Anti-BCMA (C11D5.3 scFv) CAR Expression).
  • Clone
    3G8C1
  • Species
    Mouse
  • Isotype
    Mouse IgG1 | Mouse kappa
  • Specificity
    Specifically recognizes the antigen-recognition domain of C11D5.3 derived CARs.
  • Immunogen

    Recombinant C11D5.3 scFv derived from HEK293 cells.

  • Conjugate

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • Isotype Control

    The Isotype control is sold separately and you can search for Cat. No. DNP-PM1 for product information.

  • Recommended Dilution
    1:50
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 0.2% BSA, 0.03% Proclin 300 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 24 months in lyophilized state;
    2. -70°C for 12 months after reconstitution.
    3. 2-8 °C for 12 months after reconstitution.
Bioactivity-FACS
 C11D5.3 scFv FACS

Flow cytometric analysis of Anti-BCMA(C11D5.3) CAR-293 cells staining with PE-Labeled Monoclonal Anti-C11D5.3 scFv Antibody, Mouse IgG1 (3G8C1) (Cat. No. C13-PCFMY2) at 1:50 dilution (2 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with Isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

 C11D5.3 scFv FACS

Non-specificity of PE-Labeled Monoclonal Anti-C11D5.3 scFv Antibody, Mouse IgG1 (3G8C1) (Cat. No. C13-PCFMY2) binding to CD3+ cells present in human PBMC. 5e5 of human PBMCs were simultaneously stained with FITC-Labeled Monoclonal Anti-Human CD3 Antibody and PE-Labeled Monoclonal Anti-C11D5.3 scFv Antibody, Mouse IgG1 (3G8C1) (2 μL of the antibody stock solution corresponds to labeling of 5e5 cells in a final volume of 100 µL) and washed and then analyzed with FACS. Both FITC and PE positive signals was used to evaluate the non-specific binding activity to human CD3+ cells (QC tested).

Compared Data
 C11D5.3 scFv COMPARED_DATA

Flow cytometric analysis of Anti-BCMA (C11D5.3) CAR-293 cells staining with PE-Labeled Monoclonal Anti-C11D5.3 scFv Antibodies. PE signal was used to evaluate the binding activity of anti-C11D5.3 scFv antibody. The biological activity level of C13-PCFMY2 is superior to Competitor B (Routinely tested).

  • Background
    C11D5.3 is an IgG1 mouse monoclonal antibody specific for BCMA, which is a target for the immunotherapy of multiple myeloma and lymphomas. C11D5.3 scFv is the most commonly used ectodomain componse of BCMA-specific CARs. So far, multiple reported CART BCMA trials contain the anti-BCMA scFv derived from C11D5.3, such as FDA approved CARs Abecma.
  • Clinical and Translational Updates

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