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Your Position: Home > Bio-Markers & CD Antigens > IL-21 R > Human IL21R /CD360 Protein

Human IL-21 R Protein

  • Synonym
    IL21R,CD360,NILR
  • Source
    Human IL-21 R, His Tag (ILR-H5226) is expressed from human 293 cells (HEK293). It contains AA Cys 20 - Pro 236 (Accession # AAH04348).
    Predicted N-terminus: Cys 20
  • Molecular Characterization
    IL-21 R(Cys 20 - Pro 236) AAH04348

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 25.8 kDa. The protein migrates as 42-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human IL-21 R, His Tag (Cat. No. ILR-H5226) SDS-PAGE gel

Human IL-21 R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

Bioactivity
Human IL-21 R, His TagHuman IL-21 R, His Tag (Cat. No. ILR-H5226) ELISA bioactivity

Immobilized Biotinylated Human IL-21, Fc Tag (Cat. No. IL1-H82F7) at 2 μg/mL (100 μL/well) can bind Human IL-21 R, His Tag (Cat. No. ILR-H5226) with a linear range of 2-8 ng/mL (QC tested).

  • Background
    Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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