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Your Position: Home > Other Recombinant Proteins > Human Myocilin /MYOC Protein

Human Myocilin / MYOC Protein

  • Synonym
    MYOC,Myocilin,GLC1A,GPOA,JOAG,JOAG1,TIGR
  • Source
    Human Myocilin, His Tag (MYC-H5222) is expressed from human 293 cells (HEK293). It contains AA Arg 33 - Met 504 (Accession # NP_000252).
    Predicted N-terminus: Glu 214
  • Molecular Characterization
    Myocilin(Arg 33 - Met 504) NP_000252

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 32 kDa. The protein migrates as 33 kDa under reducing (R) condition (SDS-PAGE) due to most of the MYOC was cleaved at Glu 214, generating a C-terminal fragment.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Myocilin, His Tag (Cat. No. MYC-H5222) SDS-PAGE gel

Human Myocilin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Myocilin, trabecular meshwork inducible glucocorticoid response is also known as MYOC, GLC1A, GPOA, JOAG, JOAG1, TIGR. Myocilin / MYOC contains one olfactomedin-like domain. Myocilin is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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