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Your Position: Home > Receptor Tyrosine Kinases > FGF R5 > FG1-H5250

Human FGF R5 / FGF RL1 Protein, Fc Tag

INTRODUCTION

QC & Assay Protocol

Citation & Background

Synonym
FGFR5,FGFRL1,FHFR
Source
Human FGF R5, Fc Tag (FG1-H5250) is expressed from human 293 cells (HEK293). It contains AA Ala 25 - Pro 378 (Accession # AAH36769).
Predicted N-terminus: Ala 25
Request for sequence
Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 65.5 kDa. The protein migrates as 85-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
1. -20^°C to -70^°C for 12 months in lyophilized state;
2. -70^°C for 3 months under sterile conditions after reconstitution.

SDS-PAGE

Human FGF R5, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Background
Fibroblast growth factor receptor 5 (FGFR-5) is also known as Fibroblast growth factor receptor-like 1 (FGFRL1), FGF homologous factor receptor (FHFR), is a single-pass type I membrane protein. FGFRL1 / FGFR5 contains three Ig-like C2-type (immunoglobulin-like) domains. FGFR-5 is expressed preferentially in cartilaginous tissues and pancreas and highly expressed in the liver, kidney, heart, brain and skeletal muscle. FGF RL1 / FGFR5 has a negative effect on cell proliferation. FGFR5 interacts with FGF2 with a low affinity.
References
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.