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Your Position: Home > Protein > Cadherin-11 > CA1-C52H3

Cynomolgus Cadherin-11 Protein, His Tag (MALS verified)

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  • Synonym
    Cadherin-11
  • Source
    Cynomolgus Cadherin-11 Protein, His Tag(CA1-C52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 54 - Thr 617 (Accession # A0A2K5TN17).
    Predicted N-terminus: Gly 54
  • Molecular Characterization
    Cadherin-11 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 63.8 kDa. The protein migrates as 70-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method / rFC method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cadherin-11 SDS-PAGE

Cynomolgus Cadherin-11 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
Cadherin-11 MALS images

The purity of Cynomolgus Cadherin-11 Protein, His Tag (Cat. No. CA1-C52H3) is more than 90% and the molecular weight of this protein is around 60-90 kDa verified by SEC-MALS.

  • Background
    Cadherin-11 is a type II cadherin which mediates cell-to-cell homophilic interactions. Cadherin-11 is mainly expressed on mesenchymal cells and is essential for tissue migration and organization during embryogenesis, while its expression on epithelial cancer cells is implicated in tumor progression and metastasis suggesting a potential role in the epithelial-to-mesenchymal transition phenomenon. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. In addition, cadherin-11 has been shown to increase the invasive capacity of Fibroblast-like Synoviocytes (FLS) and consequently be involved in the formation of the rheumatoid pannus.
  • Clinical and Translational Updates

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Price(USD) : $360.00

Price(USD) : $2615.00

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