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Your Position: Home > Bio-Markers & CD Antigens > NKp46 > Human NCR1 /NKp46 /CD335 Protein, with C-Fc Tag

Human NKp46 / NCR1 / CD335 Protein, Fc Tag

  • Synonym
    NCR1,LY94,CD335,NK-p46,hNKp46
  • Source
    Human NKp46, Fc Tag (NC1-H5257) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asn 254 (Accession # AAH64806).
    Predicted N-terminus: Gln 22
  • Molecular Characterization
    NKp46(Gln 22 - Asn 254) AAH64806

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 53 kDa. The protein migrates as 53-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human NKp46, Fc Tag (Cat. No. NC1-H5257) SDS-PAGE gel

Human NKp46, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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