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Your Position: Home > All Other Proteins > CD300c > Human CD300C /CLM-6 /IGSF16 Protein

Human CD300c / LMIR2 Protein

  • Synonym
    CD300C,CLM-6,CMRF35-A1,CMRF-35,CMRF35A,IGSF16
  • Source
    Human CD300c, His Tag (CDC-H5224) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Arg 183 (Accession # AAH22279).
    Predicted N-terminus: Gly 21
  • Molecular Characterization
    CD300c(Gly 21 - Arg 183) AAH22279

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 18.7 kDa. The protein migrates as 25-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human CD300c, His Tag (Cat. No. CDC-H5224) SDS-PAGE gel

Human CD300c, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    CMRF35-like molecule 6 (CLM-6) is also known as CD300 antigen-like family member C, CMRF35-A1, Immunoglobulin superfamily member 16 (IgSF16) , CD antigen CD300c, which belongs to the CD300 family. CLM-6 contains one Ig-like V-type (immunoglobulin-like) domain. CD300a/c RNA and surface expression were downregulated after stimulation of plasmacytoid dendritic cells (pDCs) with TLR7 and TLR9 ligands. Exogenous interferon (IFN)-alpha down-regulated CD300a/c expression. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300a and CD300c are indistinguishable on the surface of NK cells.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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