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Targets of TME pathways

Targets of TME pathways

Background

According to the data from The Global Cancer Observatory (GCO), cancer is now one of the most serious diseases worldwide with around 20 million new cases and nearly 9.6 million deaths. In addition to a wide range of genetic and epigenetic alterations, components of the tumor microenvironment have a major impact on tumor progression. The tumor microenvironment (TME) is the environment around tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). These cellular and non-cellular components of TME can reprogram the processes of tumor occurrence and development by regulating different cascade signaling pathways. Therefore, understanding the underlying cellular and molecular mechanisms governing these interactions can be used as a novel strategy to disrupt cancer development and contribute to the development of efficient and safe therapeutic strategies to fight cancer.
Nowadays, the TME becomes a hot area for antibody drug development and cancer treatment. ACROBiosystems have developed a series of TME related targets, such as TGF-β, Notch, etc., helping for cancer treatment and fast your R&D procedure.

Hot Targets

TGF-β

  1. > Cytokines with pleiotropic biological activities

  2. > Promote angiogenesis and migration in TME

  3. > Inhibit immune system by regulating the function of immune cell groups in the TME


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Notch

  1. > Regulate the cell differentiation, apoptosis, proliferation and cell boundary formation

  2. > High expression in malignant tumors

  3. > Interact with FGF and Wnt signaling pathways, maintain cancer stem cell (CSC) growth and reshape the TME

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Integrin

  1. > Cell adhesion molecules

  2. > Cell adhesion receptor with the function of signal transduction

  3. > Have a crucial role in tumor angiogenesis, progression, and metastasis


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VEGF

  1. > A potent angiogenic factor

  2. > Play a crucial role in promoting angiogenesis and regeneration

  3. > Have some other multiple functions such as immune regulation and neuroprotection


Products Features

Product List

Click on the molecule to find some details

Targets of Integrin signaling pathways
Integrin alpha 10 beta 1Integrin alpha 11 beta 1HOTIntegrin alpha 1 beta 1Integrin alpha 2b beta 3Integrin alpha 2 beta 1Integrin alpha 3 beta 1Integrin alpha 4 beta 1Integrin alpha 4 beta 7HOTIntegrin alpha 5 beta 1Integrin alpha 6 beta 1Integrin alpha 8 beta 1Integrin alpha 9 beta 1Integrin alpha D beta 2Integrin alpha E beta 7Integrin alpha L beta 2Integrin alpha M beta 2Integrin alpha V beta 1HOTIntegrin alpha V beta 3HOTIntegrin alpha V beta 5HOTIntegrin alpha V beta 6HOTIntegrin alpha V beta 8Integrin alpha X beta 2Integrin isoform alpha-7X2B beta 1
Targets of TGF-β signaling pathways
LAP (TGF-beta 1)Latent TGF-beta 1TGF-beta 1HOTTGF-beta 2TGF-beta 3TGF-beta RIIHOT
Targets of Notch signaling pathways
NOTCH1 NOTCH2 NOTCH3 DLL1 DLL3HOT DLL4 Jagged 1 Thrombospondin-2 Netrin receptor DCC Netrin-1
Targets of VEGF signaling pathways
VEGF110 VEGF120 VEGF121 VEGF164 VEGF165HOT VEGF-B VEGF-CHOT VEGF-D VEGF R1 VEGF R2 VEGF R3
Targets of other important signaling pathways
EGF EGF RHOT EGFRvIII HGF HGF R wnt FGF hedgehog

Validation Data

High purity——MALS verified
DLL3（DL3-H52H4）
High purity——MALS verified
The purity of Human DLL3, His Tag(Cat. No. DL3-H52H4) is more than 95% and the molecular weight of this protein is around 55-65 kDa verified by SEC-MALS.
Bioactivity verification
> ELISA
TGF-beta 1（TG1-H4212）
High purity——MALS verified
Immobilized ActiveMax® Human TGFB1, Tag Free (Cat. No. TG1-H4212) at 0.2 μg/mL (100 μL/well) can bind Human TGFBR2, Fc Tag (Cat. No. TG2-H5252) with a linear range of 0.08-1 ng/mL (QC tested).
Protocol

> BLI
NOTCH2（NO2-H5255）
High purity——MALS verified
Loaded Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) on Protein A Biosensor, can bind Human DLL4, His Tag (Cat. No. DL4-H5227) with an affinity constant of 77.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Protocol
> SPR
HGF R（MET-H5256）
High purity——MALS verified
Human HGF R Protein, Fc Tag (Cat. No. MET-H5256) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human HGF Protein, His Tag (Cat. No. HGF-H52H3) with an affinity constant of 75.2 pM as determined in a SPR assay (Biacore 8K) (QC tested).
Protocol
  • Signaling Pathways
  • Background
  • Hot Targets
  • Products Features
  • Product List
  • Validation Data