1. This asset showed more potent activity than OCA during in vivo assays.
2. More potent efficacy than GS9674 or OCA in different NASH animal models with lower doses.
3. Wider safety window than OCA (67.6 fold VS 4.8 fold) and comparable lower estimated human dose(0.25 mg VS 25 mg).
4. Efficacy has been showed in different animal NASH model.
The asset showed more potent efficacy than GS9674 and OCA in different NASH animal models with lower doses.
5. Development Timeline
1. Asset type: FXR Agonist
2. Indication: NASH
3. Modality: Small molecular
4. Research phase: Phase I is finished in AU/Phase II is ongoing in CN
5. Cooperation demands: License-out or co-development
6. Research progress：
(1) Phase I is finished in CN and AU.
(2) Phase II is ongoing in CN.
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