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Your Position: Home > B7-H2

B7-H2

B7-H2 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
B72-H5254 Human Human B7-H2 / ICOSLG Protein, Fc Tag
B72-H5254-structure
B72-H5254-sds
B72-H5254-elisa_1
B72-H5221 Human Human B7-H2 / ICOSLG Protein
B72-H5221-structure
B72-H5221-sds
B72-H5221-elisa_1

B7-H2 Molecule Synonym Name

ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand

B7-H2 Molecule Background

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

B7-H2 References

B7-H2 Related Molecule

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