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Your Position: Home > B7-H2


Brief Information

Name:ICOS ligand
Target Synonym:Inducible T-Cell Co-Stimulator Ligand,B7-like protein Gl50,B7-H2,B7RP-1,B7-related protein 1,B7H2,GL50,B7RP1,CD275 Antigen,ICOSL,Inducible T-Cell Costimulator Ligand,B7h,B7 Homologue 2,KIAA0653,Inducible T Cell Costimulator Ligand,Transmembrane Protein B7-H2 ICOS Ligand,ICOS-L,LICOS,B7 homolog 2,CD275,ICOSLG
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data


Immobilized Human ICOS, Fc Tag (Cat. No. ICS-H5258) at 1 μg/mL (100 μL/well) can bind Cynomolgus B7-H2, His Tag (Cat. No. B72-C52Hb) with a linear range of 0.6-20 ng/mL (QC tested).


Immobilized Mouse ICOS (C137S, C138S), His Tag (Cat. No. ICS-M52H8) at 5 μg/mL (100 μL/well) can bind Rat B7-H2, Fc Tag (Cat. No. B72-R5259) with a linear range of 0.6-39 ng/mL (QC tested).

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Synonym Name



ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

Clinical and Translational Updates

Related Molecule

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Rozibafusp alfa AMG-570; MEDI-0700 Phase 2 Clinical Amgen Inc Arthritis, Rheumatoid; Lupus Erythematosus, Systemic Details

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