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Your Position: Home > All Other Proteins > Coagulation Factor II > THN-H52H0

Human Coagulation Factor II / Thrombin Protein, His Tag

INTRODUCTION

QC & Assay Protocol

Citation & Background

This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.

Synonym
thrombin,Coagulation factor II
Source
Human Coagulation Factor II, His Tag (THN-H52H0) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Glu 622 (Accession # AAH51332).
Predicted N-terminus: Gln 25
Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 69.5 kDa.
Endotoxin

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20^°C to -70^°C for 12 months in lyophilized state;
2. -70^°C for 3 months under sterile conditions after reconstitution.

Background
Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing.
References
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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THN-H52H0-50ug

Price(USD) : $350.00

THN-H52H0-500ug

Price(USD) : $1200.00

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Drug Development Status

Number of Launched Drugs：40 Details
Number of Drugs in Clinical Trials：64 Details
Latest Research Phase：Approved

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English Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Human prothrombin complex (Tonrol Biopharmaceuticals)		Approved	Tonrol		cfda	Bleeding, Hemophilia B, Congenital factor VII deficiency, Factor X deficiency		2015-06-25	Factor X deficiency, Hemophilia B, Congenital factor VII deficiency, Bleeding	Details
Enoxaparin sodium biosimilar (Gland Pharma)		Approved	Gland Pharma						Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI)	Details
Thrombomodulin Alfa	ART-123; TMD-123; AT-908,ART123	Approved	Asahi Kasei	Thrombomodulin Alfa	日本	Disseminated intravascular coagulation (DIC)	旭化成	2008-01-25 00:00:00.0	Disseminated intravascular coagulation (DIC)	Details
Beriplast-P		Approved	CSL Behring						Wound Healing, Bleeding	Details
Fibrin patch (Ethicon/Omrix Biopharmaceuticals)		Approved	Johnson & Johnson	human fibrinogen / human thrombin	ema	Supportive treatment in adult surgery where standard surgical techniques are insufficient (see section 5.1): - for improvement of haemostasis.	Omrix Biopharmaceuticals N. V.	2013-09-25	Bleeding	Details
Dermatan sulfate	MF-701; MF-777	Approved	Mediolanum Farmaceutici	Dermatan sulfate	意大利	Thrombosis, Venous thromboembolism (VTE), Thrombocytopenia	Mediolanum Farmaceutici	1998-07-01 00:00:00.0	Thrombocytopenia, Venous thromboembolism (VTE), Thrombosis	Details
Hirudin biosimilar (Rhein-Minapharm)		Approved	Rhein Minapharm Biogenetics						Deep vein thrombosis (DVT)	Details
Argatroban	DK-7419; GN1600; MCI-9038; MD-805; MDI-805; OM-805	Approved	Mitsubishi Tanabe Pharma, Pfizer	Argatroban	日本			1990-01-01 00:00:00.0	Percutaneous coronary intervention (PCI), Thrombosis	Details
Human fibrinogen/Human thrombin (Instituto Grifols)		Approved	Grifols	human fibrinogen, human thrombin	ema	Supportive treatment in adults where standard surgical techniques are insufficient: for improvement of haemostasis as suture support in vascular surgery	Instituto Grifols, S.A.	2017-11-10	Bleeding	Details
Antithrombin Gamma	KW-3357	Approved	Kyowa Hakko Kirin	Antithrombin Gamma	日本	Hereditary antithrombin deficiency, Disseminated intravascular coagulation (DIC)	协和发酵麒麟	2015-07-03 00:00:00.0	Disseminated intravascular coagulation (DIC), Hereditary antithrombin deficiency	Details
Antithrombin III (CSL Behring)	BI51.017	Approved	CSL Behring	Antithrombin III (CSL Behring)	日本	Thrombosis, Disseminated intravascular coagulation (DIC)	CSL Behring	1987-08-02 00:00:00.0	Disseminated intravascular coagulation (DIC), Thrombosis, Thrombosis	Details
Human fibrinogen concentrate (CSL Behring)		Approved	CSL Behring	Riastap	hma	Afibrinogenaemia	CSL Behring Emil-von-Behring-Straße 76 35041 Marburg Germany	2010-07-27	Afibrinogenaemia	Details
Enoxaparin sodium biosimilar (Sahar International Trading)		Approved	Sahar International Trading						Unstable angina, ST-segment elevation myocardial infarction (STEMI), Venous thromboembolism (VTE), Blood coagulation disorders	Details
Fibrin sealant patch (Takeda)		Approved	Nycomed Pharmaceutical, Takeda	human fibrinogen;human thrombin	ema		Takeda Austria GmbH	2004-06-08	Bleeding	Details
Andexanet alfa	PRT-064445; PRT-4445; PRT-44545,PRT064445,PRT4445	Approved	Portola Pharmaceutical	andexanet alfa	ema	For adult patients treated with a direct factor Xa (FXa) inhibitor (apixaban or rivaroxaban) when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.	Portola Netherlands B.V.	2019-04-26	Hemorrhagic disorder	Details
Enoxaparin sodium biosimilar (Harvest Moon Pharmaceuticals)		Approved	Harvest Moon						Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI)	Details
Enoxaparin sodium biosimilar (Chandra Bhagat Pharma)		Approved	Chandra Bhagat Pharma（CBC）						Deep vein thrombosis (DVT)	Details
Desirudin	CGP-39393	Approved	Unknown	desirudin	ema	Prevention of deep venous thrombosis in patients undergoing elective hip or knee replacement surgery.	Canyon Pharmaceuticals Ltd.	1997-07-09	Venous thromboembolism (VTE)	Details
Human fibrinogen concentrate (LFB Biomedicaments)	FGTW; FibCLOT	Approved	LFB Biotechnologies, Innsbruck Medical University	FibCLOT	hma	Afibrinogenaemia, Blood coagulation disorders	Laboratoire Francais du Fractionnement et des Biotechnologies 3 Avenue des Tropiques ZA de Courtaboeuf 91940 Les Ulis, France	2015-12-22	Afibrinogenaemia, Blood coagulation disorders	Details
Enoxaparin Sodium	PK-10169; RP-54563; XRP-4563K; M-enoxaparin; PRY-005; RPY-005	Approved	Sanofi	LOVENOX (PRESERVATIVE FREE)	fda		SANOFI AVENTIS US	1993-03-29	Unstable angina, ST-segment elevation myocardial infarction (STEMI), Venous thromboembolism (VTE)	Details
Human fibrin sealant kit (Hualan Biological Engineering)		Approved	Hualan Biological Engineering	Human Fibrin Sealant Kit	cfda	wound, Bleeding		2015-05-26	wound, Bleeding	Details
Bivalirudin	BG-8967; Hirulog-1	Approved	The Medicines Company	ANGIOMAX	fda	Percutaneous coronary intervention (PCI), Unstable angina, Percutaneous transluminal coronary angioplasty (PTCA)	SANDOZ INC	2000-12-15	Percutaneous coronary intervention (PCI), Thrombocytopenia, Percutaneous transluminal coronary angioplasty (PTCA), Thromboembolism	Details
Liquid fibrin sealant (OMRIX Biopharmaceuticals)		Approved	OMRIX Biopharmaceuticals, Ethicon	Quixil	hma	Bleeding	Omrix Biopharmaceuticals S.A. 200 Chaussee de Waterloo 1640 Rhode St Genese Belgium	2000-12-07	Bleeding	Details
Antithrombin III (Human, Grifols)		Approved	Grifols						Hereditary antithrombin deficiency, Thromboembolism	Details
Human coagulation factor X (Bio Products Laboratory)		Approved	Bio Products Laboratory	Human coagulation factor X	ema		BPL Bioproducts Laboratory GmbH	2016-03-16	Factor X deficiency	Details
Human fibrinogen/Human thrombin (Mallinckrodt)	PRO-0601	Approved	Mallinckrodt	human fibrinogen;human thrombin	ema		Mallinckrodt Pharmaceuticals Ireland Limited	2015-03-19	Surgical blood loss	Details
Enoxaparin sodium biosimilar (Blau Pharmaceuticals)		Approved	Blau Pharmaceuticals						Thrombosis	Details
Human prothrombin complex concentrate (Guizhou Taibang Biological Products)		Approved	Guizhou Taibang Biological Products						Prothrombin complex deficiency	Details
Prothrombin complex concentrate (Sanquin)		Approved	Sanquin	Cofact	hma	Bleeding	Sanquin Plesmanlaan 125 1066 CX Amsterdam The Netherlands	2006-11-19	Bleeding	Details
Enoxaparin sodium biosimilar (Pharmathen)		Approved	Pharmathen	enoxaparin sodium	ema		Pharmathen S.A.	2016-09-14	Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI)	Details
Enoxaparin sodium biosimilar (PT Kalbe)		Approved	Kalbe Farma						Unstable angina, Deep vein thrombosis (DVT), Myocardial infarction (MI)	Details
Human prothrombin complex (Octapharma)		Approved	Octapharma	Human prothrombin complex (Octapharma)	德国	Bleeding	Octapharma	2003-03-14 00:00:00.0	Bleeding	Details
Human prothrombin complex concentrate (Shanxi Kangbao Biological Products)		Approved	Shanxi Kangbao Biological Product	Human Prothrombin Complex	cfda	Bleeding, Surgical blood loss		2019-09-17	Surgical blood loss, Bleeding	Details
Enoxaparin sodium biosimilar (Rovi)		Approved	Rovi						Unstable angina, Deep vein thrombosis (DVT), Myocardial infarction (MI)	Details
Antithrombin alfa	rhATIII	Approved	Genzyme, rEVO Biologics	Antithrombin alfa	ema		Laboratoire Francais du Fractionnement et des Biotechnologies	2006-07-28	Hereditary antithrombin deficiency	Details
Fibrinogen (Octapharma)		Approved	Octapharma						Afibrinogenaemia	Details
Prothrombin complex concentrat (Taibang Biological Products)		Approved	Shandong Taibang Biological Products	Human Prothrombin Complex	cfda	Bleeding		2014-09-30	Bleeding	Details
Human fibrinogen/Human thrombin (Baxalta)		Approved	Baxalta						Bleeding	Details
Idarucizumab	BI-655075; 97RWB5S1U6 (UNII code) ,BI655075	Approved	Boehringer Ingelheim	PRAXBIND	fda	Emergency surgery, Bleeding	BOEHRINGER INGELHEIM	2015-10-16	Emergency surgery, Bleeding	Details
Enoxaparin sodium biosimilar (Neiss Labs)		Approved	Neiss Labs						Deep vein thrombosis (DVT)	Details
Dabigatran Etexilate Mesylate	BIBR-1048MS; BIBR-953; BIBR-953-ZW; BIBR-1048,BIBR 1048 MS,BIBR1048 MS	Approved	Boehringer Ingelheim	Dabigatran etexilate mesilate	ema		Boehringer Ingelheim International GmbH	2008-03-17	Pulmonary embolism, Deep vein thrombosis (DVT), Stroke and systemic embolism, Venous thromboembolism (VTE)	Details

English Name	Research Code	Research Phase	Company	Indications	Clinical Trials
GH-9001	GH-9001	Phase Ⅰ	InflaZyme, Leo Pharma	Thrombosis	Details
Efegatran sulfate hydrate	GYKI-14766; LY-294468	Phase Ⅱ	Lilly, Ivax	Thrombosis, Myocardial infarction (MI)	Details
VE-1902	VE-01902; VE-1902,VE 1902,VE1902	Phase Ⅰ	Verseon	Atrial fibrillation	Details
Ximelagatran	H-376/95; H-376; H-37695,H 376/95,H376/95	Withdrawn	AstraZeneca	Venous thromboembolism (VTE)	Details
Recombinant Hirudin-2 (AMMS)		IND Filing	Institute of Pharmacology & Radiation of AMMS	Unspecified	Details
L-376062	L-372236; L-377009; L-376062; L-375378; L-373722; L-372460	Phase Ⅰ	Merck Sharp & Dohme	Thrombosis	Details
TRI-50b	TRI-50b; TRI-50; TRI-B50,TRI50b	Phase Ⅱ	Trigen Holdings AG	Thrombosis	Details
Napsagatran	RO-466240; RO-46-6240/010	Phase Ⅱ	Roche	Thrombosis, Myocardial infarction (MI)	Details
Flovagatran sodium	TGN-255,TGN255	Phase Ⅱ	Trigen Holdings AG	Thrombosis	Details
BCH-2763	BCH-2763	Preclinical	Shire	Thrombosis	Details
Recombinant hirudin (Fosun Pharma)		IND Filing	Fosun Pharma	Thrombosis	Details
Sofigatran	MCC-977	Phase Ⅱ	Mitsubishi Tanabe Pharma	Deep vein thrombosis (DVT)	Details
DP-4088	DPOC-4088; DP-4088,DP4088,DPOC4088	Phase Ⅰ	Merck Sharp & Dohme, Diakron, Orchid	Blood coagulation disorders	Details
Recombinant human thrombin (Suzhou Zelgen Biopharmaceutical)		Phase Ⅲ	Zelgen Biosciences	Surgical blood loss	Details
Recombinant bifunctional hirudin (Fudan University)		Phase Ⅰ	Fudan University	Unspecified	Details
CTB-001	CTB-001; CT-001	Phase Ⅰ	C-TRI	Thrombosis	Details
Vasoflux		Phase Ⅱ	InflaZyme	Myocardial infarction (MI), Thrombosis	Details
LB-30057	CI-1028; LB-30057; PD-172524	Phase Ⅰ	LG Chem, Pfizer	Thrombosis	Details
UK-156406	UK-156406	Phase Ⅰ	Pfizer	Thrombosis	Details
GW-473178	GW-473178	Phase Ⅰ	GlaxoSmithKline	Venous thromboembolism (VTE), Atrial fibrillation	Details
Enoxaparin sodium biosimilar (Techdow)		BLA Filing	Shenzhen Techdow	Unstable angina, Deep vein thrombosis (DVT), Venous thromboembolism (VTE), Myocardial infarction (MI)	Details
SR-123781	SR-123781; SR-123781A; SanOrg-123781; HDS; SANORG 123781A	Phase Ⅲ	Sanofi	Acute coronary syndrome (ACS), Thrombosis	Details
PF-05230907	PF-05230907; PF-5230907; PF-907	Phase Ⅰ	Pfizer	Cerebral haemorrhage	Details
EP-217609	Org-217609; EP-217609; EP217609C101,Org217609; EP21796	Phase Ⅱ	Merck Sharp & Dohme, Endotis	Thrombosis	Details
ORG-27306	ORG-27306	Phase Ⅰ	Merck Sharp & Dohme	Thrombosis	Details
V-19	V-19	Phase Ⅱ	InflaZyme	Thrombosis	Details
CX-397	CX-397,CX 397,CX397	Phase Ⅱ	Kaken Pharmaceutical	Disseminated intravascular coagulation (DIC), Thrombosis	Details
TRIB-50	TRI-50; TRI-B50	Phase Ⅱ	Thrombosis Research Institute, Trigen Holdings AG	Thrombosis	Details
Org-36764	Org-36764	Phase Ⅰ	Merck Sharp & Dohme	Thrombosis	Details
Odiparcil	SB-424323; IVA-336	Phase Ⅱ	Abbvie, GlaxoSmithKline	Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)	Details
Deligoparin sodium	OP-2000	Phase Ⅲ	Opocrin SpA, Aeolus Pharmaceuticals, Perrigo	Cardiovascular disorders, Ulcerative colitis, Inflammatory bowel disease	Details
Thrombomodulin (Mochida/JCR)	MB-015; MR-33; TMD1-105; rhu-TM	BLA Filing	Mochida, JCR Pharmaceuticals	Disseminated intravascular coagulation (DIC)	Details
Peptide-based blood coagulant (Haemostatix)		Phase Ⅱ	Haemostatix, Boryung Pharmaceutical	Surgical blood loss	Details
BSF-208791	BSF 208791; BSF208791	Phase Ⅰ	Abbvie	Thrombosis	Details
rHV2-Lys-47	rHV2-Lys-47	Phase Ⅰ	Sanofi, Transgene	Disseminated intravascular coagulation (DIC), Thrombosis	Details
EGR-Xa	EGR-Xa	Phase Ⅰ	COR Therapeutics Inc	Thromboembolism	Details
SSR-182289A	SSR-182289A; SSR-182289,SSR182289A,SSR182289	Phase Ⅱ	Sanofi	Thrombosis	Details
CVS-1578	CVS-1578	Phase Ⅰ	Merck Sharp & Dohme, Dendreon Corporation	Thromboembolism	Details
SSR-128429	SSR-128429	Phase Ⅰ	Sanofi	Thromboembolism	Details
Dabigatran etexilate tosylate (Huons)	RDG-17012	Phase Ⅰ	Huons	Thromboembolism	Details
Targeted NIF-hirulog hybrid (Chongqing Fujin Biomedical)	rNIF-hirulog; TNHH	Phase Ⅰ	Chongqing Fujin Biomedical	Stroke	Details
Heparinase I		Phase Ⅲ	IBEX Technologies, BioMarin Pharmaceutical	Blood coagulation disorders	Details
Semuloparin sodium	AVE-5026	NDA Filing	Sanofi	Thromboembolism	Details
ARC-183	ARC-183	Phase Ⅰ	Archemix	Thrombosis	Details
AZD-8165	AZD-8165	Phase Ⅰ	AstraZeneca	Thrombosis	Details
Recombinant hirudin (Guangzhou Recomgen Biotech)		IND Filing	Guangzhou Recomgen Biotech	Thrombosis	Details
Recombinant hirudin (Shandong Ahua Biochemical)		IND Filing	Angde Biopharmaceutical	Thrombosis	Details
MPC-0920	MPC-0920	Phase Ⅰ	Myriad Genetics	Thrombosis	Details
CVS-1123	CVS-1123	Phase Ⅰ	Merck Sharp & Dohme	Unstable angina, Coronary artery disease (CAD), Venous thromboembolism (VTE)	Details
Recombinant hirudin (Kerun Biopharmaceutical)		IND Filing	Kerun Biopharmaceutical	Thrombosis	Details
EP-42675	Org-42675; EP-42675,EP42675,Org42675	Phase Ⅰ	Merck Sharp & Dohme, Endotis	Thrombosis	Details
3DP-4815	3DP-4815; JNJ-6368661; RWJ-422521; TDP-4815	Phase Ⅰ	Johnson & Johnson	Arterial thrombosis, Venous thromboembolism (VTE)	Details
Enoxaparin sodium biosimilar (Biocad)	BCD-080	Phase Ⅲ	Biocad	Deep vein thrombosis (DVT), Venous thromboembolism (VTE)	Details
Recombinant staphylokinase-hirudin fusion protein		IND Filing	Humanwell Healthcare, Institute of Pharmacology & Radiation of AMMS	Thromboembolism	Details
S-18326	S-18326	Phase Ⅰ	Servier	Thrombosis	Details
NU-172	ARC-2172; NU-172	Phase Ⅱ	Archemix, ARCA biopharma	Heart disease	Details
Ichorcumab	JNJ-64179375; JNJ-9375; JNJ-375,JNJ64179375; JNJ9375; JNJ375,JNJ 64179375; JNJ 9375; JNJ 375	Phase Ⅱ	Cambridge University Hospitals, University of Cambridge, Janssen	Thrombosis	Details
Inogatran	Inogatran; H-314/27; HA-31427	Phase Ⅱ	AstraZeneca	Unstable angina, Myocardial infarction (MI)	Details
EH		Phase Ⅰ	Academy of Military Medical Sciences, Beijing Sanyouliheze Biological Technology	Deep vein thrombosis (DVT)	Details
RWJ-27755	PPACK; RWJ-27755	Preclinical	Johnson & Johnson	Thrombosis	Details
CJC-1004	CJC-1004; CCI-1004; DAC:T1	Phase Ⅱ	ConjuChem	Thrombosis	Details
MER-102		Phase Ⅰ	Merrion Pharmaceuticals	Thrombosis	Details
Adomiparin sodium	M-118	Phase Ⅱ	Momenta	Acute coronary syndrome (ACS)	Details