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VIN-H5119-100ug
$85.00
VIN-H5119-1mg (500ug × 2)
$350.00
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  • Performance Data
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分子别名(Synonym)

VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor

表达区间及表达系统(Source)

Human Vitronectin, Tag Free (VIN-H5119) is expressed from E. coli cells. It contains AA Asp 20 -Arg 398 (Accession # P04004-1).

Predicted N-terminus: Met

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蛋白结构(Molecular Characterization)

Online(Asp 20 -Arg 398) P04004-1

This protein carries no "tag".

The protein has a calculated MW of 43.2 kDa. The protein migrates as 48-50 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 20 mM Tris-HCl, Arginine, pH8.0 .

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.

Background

Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.