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Your Position: Home > Cytokines > IL-38 > IL8-H5243

Human IL-38 / IL-1F10 Protein, His Tag

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  • Synonym
    IL-38 , IL-1F10,IL-1 theta,Interleukin-1 family member 10,Family of interleukin 1-theta,Interleukin-1 HY2,Interleukin-38,FIL1T, IL1HY2, IL38
  • Source
    Human IL-38, His Tag (IL8-H5243) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Trp 152 (Accession # Q8WWZ1-1).
  • Molecular Characterization
    Online-Res(Met 1 - Trp 152) Q8WWZ1-1

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 18.8 kDa.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Interleukin 38 (IL-38) is a newly discovered IL-1 family cytokine, expressed in several tissues and secreted by various cells. IL-38 exerts anti-inflammatory function by binding to a variety of receptors, including interleukin 36 receptor (IL-36R), interleukin 1 receptor accessory protein-like 1 (IL-1RAPL1) and interleukin 1 receptor 1 (IL-1R1)) Combines with other pro-inflammatory cytokines and inhibits subsequent signaling pathways; thereby regulating the differentiation and function of T cells, peripheral blood monocytes, macrophages and dendritic cells. Inflammatory autoimmune disease is a common immune-mediated inflammatory syndrome characterized by an imbalance between helper T cells (Ths) (especially Th1s and Th17s) and regulatory T cells (Tregs). Recent findings indicate that IL-38 is abnormally expressed in inflammatory autoimmune diseases, such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, primary Sjogren’s syndrome, psoriasis and inflammatory bowel disease , Hidradenitis suppurativa, ankylosing spondylitis and glaucoma, including Th1. Tregs.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $350.00

Price(USD) : $2310.00

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