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Your Position: Home > Signal Transduction > Amyloid Precursor Protein > AMR-H52H4

Human Amyloid Precursor Protein, His Tag (MALS verified)

  • Synonym
    Amyloid Precursor Protein,Alzheimer disease amyloid protein,APP,Amyloid-beta precursor protein
  • Source
    Human Amyloid Precursor, His Tag (AMR-H52H4) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Ala 701 (Accession # P05067-1).
    Predicted N-terminus: Leu 18
  • Molecular Characterization
    Online(Leu 18 - Ala 701) P05067-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 79.3 kDa. The protein migrates as 80-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.3 M Arginine, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Amyloid Precursor, His Tag (Cat. No. AMR-H52H4) SDS-PAGE gel

Human Amyloid Precursor, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human Amyloid Precursor, His Tag (Cat. No. ) MALS images

The purity of Human Amyloid Precursor, His Tag (Cat. No. AMR-H52H4) is more than 85% and the molecular weight of this protein is around 87-107 kDa verified by SEC-MALS.

  • Background
    Amyloid precursor protein (APP) is a type 1 membrane protein with an NH2 -terminal extracellular domain and a COOH-terminal cytosolic tail. The amyloid precursor protein (APP) takes a key role in Alzheimer’s disease (AD) pathogenesis. Processing of APP generates that generates the Aβ peptide, whose accumulation is associated with Alzheimer’s disease.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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