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Spike,S protein RBD,Spike glycoprotein Receptor-binding domain,S glycoprotein RBD,Spike protein RBD
SARS-CoV-2 S protein RBD-VLP (SPD-C52M6) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Asn 532 (Accession # QHD43416.1).
Predicted N-terminus: Val
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 96.6 kDa. The protein migrates as 70 kDa and 100 kDa under reducing (R) condition (SDS-PAGE).
Less than 0.5 EU per μg by the LAL method.
Supplied as 0.2 μm filtered solution in Glycine, sodium citrate, pH 8.0, PBS with trehalose as protectant.
The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).
Contact us for customized product form or formulation.
This product is supplied and shipped with dry ice, please inquire the shipping cost.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
