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KL, Klotho, Klotho peptide
Human Klotho, Tag Free (KLO-H5213) is expressed from human 293 cells (HEK293). It contains AA Glu 34 - Ser 981 (Accession # Q9UEF7-1).
Predicted N-terminus: Glu 34
This protein carries no "tag".
The protein has a calculated MW of 109.8 kDa.
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Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
The Klotho protein, also known as α-Klotho, is a multifunctional protein that regulates the metabolism of phosphate, calcium, and vitamin D. Klotho may also function as a hormone. Three Klotho protein types with potentially different functions have been identified: a full-length transmembrane Klotho, a truncated soluble Klotho, and a secreted Klotho. Recent evidence suggests that Klotho suppresses the insulin and Wnt signaling pathways, inhibits oxidative stress, and regulates phosphatase and calcium absorption.