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CD47

CD47 Molecule Information

Name:Cluster of differentiation 47
Target Synonym:MER6?CD47?Leukocyte surface antigen CD47?CD47 Molecule?Antigenic Surface Determinant Protein OA3?CD47 Antigen (Rh-Related Antigen? Integrin-Associated Signal Transducer)?Antigen Identified By Monoclonal Antibody 1D8?Integrin Associated Protein?Rh-Related
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:20
Lastest Research Phase:Phase 3 Clinical

CD47 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
CD7-HF2H3 Human FITC-Labeled Human CD47 Protein, His Tag
CD7-HF2H3-structure
CD7-H82F8 Human Biotinylated Human CD47 Protein, Fc (L234A, L235A, P329G),Avitag™
CD7-H82F8-structure
CD7-H82F8-sds
CD7-H82F8-elisa_1
CD7-M82E4 Mouse Biotinylated Mouse CD47 Protein, His,Avitag™
CD7-M82E4-structure
CD7-M82E4-sds
CD7-M82E4-elisa_1
CD7-C52H5 Canine Canine CD47 Protein, His Tag
CD7-C52H5-structure
CD7-C52H5-sds
CD7-C52H5-elisa_1
EP-102 Human CD47: SIRP alpha [Biotinylated] Inhibitor Screening ELISA Assay Pair
EP-102-elisa_1
CD7-H522a Human Human CD47 Protein, His Tag, low endotoxin
CD7-H522a-structure
CD7-H522a-sds
CD7-H522a-elisa_1
CD7-H5251 Human Human CD47 Protein, Llama IgG2b Fc Tag, low endotoxin
CD7-H5251-structure
CD7-H5251-sds
CD7-H5251-elisa_1
CD7-M525a Mouse Mouse CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M525a-structure
CD7-M525a-sds
CD7-M525a-elisa_1
CD7-M522b Mouse Mouse CD47 Protein, His Tag
CD7-M522b-structure
CD7-M522b-sds
CD7-M522b-elisa_1
CD7-C52H1 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD47 Protein, His Tag
CD7-C52H1-structure
CD7-C52H1-sds
CD7-C52H1-elisa_1
CD7-C52H1-elisa_2
CD7-HA2E9 Human Unconjugated Human CD47 Protein, His,Avitag™
CD7-HA2E9-structure
CD7-HA2E9-sds
CD7-HA2E9-elisa_1
CD7-H82E9 Human Biotinylated Human CD47 Protein, His,Avitag™
CD7-H82E9-structure
CD7-H82E9-sds
CD7-H82E9-elisa_1
CD7-R5257 Rabbit Rabbit CD47 Protein, Fc Tag
CD7-R5257-structure
CD7-R5257-sds
CD7-R5256 Rat Rat CD47 Protein, Fc Tag
CD7-R5256-structure
CD7-R5256-sds
CD7-R5256-elisa_1
CD7-H52A5 Human Human CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H52A5-structure
CD7-H52A5-sds
CD7-H52A5-elisa_1
CD7-C5252 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD47 Protein, Fc Tag
CD7-C5252-structure
CD7-C5252-sds
CD7-C5252-elisa_1
CD7-M5251 Mouse Mouse CD47 Protein, Fc Tag
CD7-M5251-structure
CD7-M5251-sds
CD7-H82F6 Human Biotinylated Human CD47 Protein, Fc,Avitag™
CD7-H82F6-structure
CD7-H82F6-sds
CD7-H82F6-elisa_1
CD7-H5227 Human Human CD47 Protein, His Tag
CD7-H5227-structure
CD7-H5227-sds
CD7-H5227-elisa_1
CD7-H5227-elisa_2
CD7-H5256 Human Human CD47 Protein, Fc Tag (MALS verified)
CD7-H5256-structure
CD7-H5256-sds
CD7-H5256-hplc
CD7-H5256-elisa_1

CD47 Part of Bioactivity data

CD7-H82E9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that Biotinylated Human CD47, His,Avitag (Cat. No. CD7-H82E9) can bind to ACHN cell expressing human SIRP-a. The concentration of CD47 used is 10 μg/mL (Routinely tested).

CD7-H82E9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS analysis shows that the binding of Human CD47 to ACHN expressing SIRP-a was inhibited by increasing concentration of neutralizing SIRP-a antibody. The concentration of Human CD47 used is 20 μg/mL. IC50=9.334 μg/mL

CD7-C52H1-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-CD47 Mab (Human IgG4) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Cynomolgus/Rhesus macaque CD47, His Tag (Cat. No. CD7-C52H1) with an affinity constant of 1.8 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

CD7-H5227-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human CD47 MAb (Human IgG4) captured on CM5 chip via Anti-Human IgG Fc antibodies surface, can bind Human CD47, His Tag (Cat. No. CD7-H5227) with an affinity constant of 1.66 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

CD47 Customer Reviews

CD47 Molecule Synonym Name

CD47,MER6,IAP,OA3

CD47 Molecule Background

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

CD47 References

CD47 Related Molecule

CD47 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
IBI-188 IBI-188 Phase 3 Clinical Innovent Biologics(Suzhou) Co Ltd Neoplasms; Myelodysplastic Syndromes; Myeloproliferative Disorders; Leukemia, Myeloid, Acute Details
TJC-4 TJC-4; TJ-011133 Phase 2 Clinical I-Mab Biopharma Co Ltd Myelodysplastic Syndromes; Leukemia, Myeloid, Acute; Lymphoma Details
IMM-0306 IMM-0306 Phase 1 Clinical Yiming Angke Biomedical Technology (Shanghai) Co Ltd Lymphoma, B-Cell Details
ZL-1201 ZL-1201 Phase 1 Clinical Zai Lab (Shanghai) Co Ltd Neoplasms Details
AK-117 AK-117 Phase 1 Clinical Zhongshan Akeso Biopharma Co Ltd Solid tumours; Neoplasms; Lymphoma Details
IMC-002 IMC-002 Phase 1 Clinical Immuneoncia Therapeutics Lymphoma Details
HX-009 HX-009 Phase 1 Clinical Hangzhou Hansi Biomedicine Co Ltd, Wuhan Hanxiong Biotechnology Co Ltd Liver Neoplasms; Hematologic Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma Details
TG-1801 NI-1701; TG-1801 Phase 1 Clinical Novimmune Lymphoma, B-Cell Details
SRF-231 SRF-231 Phase 1 Clinical Surface Oncology Hematologic Neoplasms Details
IMM01 IMM01 Phase 1 Clinical Yiming Angke Biomedical Technology (Shanghai) Co Ltd Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Uveal melanoma; Colorectal Neoplasms; Lymphoma; Esophageal Squamous Cell Carcinoma Details
DSP-107 DSP-107; KAHR-107 Phase 2 Clinical Kahr Medical Carcinoma, Non-Small-Cell Lung Details
Magrolimab 5-F-9; Hu5F9-G4; ONO-7913 Phase 3 Clinical Stanford University Hematologic Neoplasms; Ovarian Neoplasms; Carcinoma, Transitional Cell; Myelodysplastic Syndromes; Neoplasms; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin Details
IBI-322 IBI-322 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Hematologic Neoplasms; Neoplasms Details
TTI-621 TTI-621 Phase 1 Clinical University Health Network, The Hospital For Sick Children Leukemia, Promyelocytic, Acute; Hematologic Neoplasms; Papillomavirus Infections; Breast Neoplasms; Sarcoma; Carcinoma, Squamous Cell; Mycosis Fungoides; Melanoma Details
TTI-622 TTI-622 Phase 1 Clinical Trillium Therapeutics Inc Bone Marrow Neoplasms; Multiple Myeloma; Lymphoma Details
Anti-CD47 monoclonal antibody (Biocad) Phase 1 Clinical Biocad Neoplasms Details
ALX-148 ALX148; ALX-148 Phase 2 Clinical Alexo Therapeutics Head and Neck Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Myelodysplastic Syndromes; Lymphoma, Non-Hodgkin; Neoplasm Metastasis Details
AO-176 AO-176; Ti-104; Ti-108; Ti-176 Phase 2 Clinical Arch Oncology Solid tumours; Neoplasms; Multiple Myeloma Details
SHR-1603 SHR-1603 Phase 1 Clinical Jiangsu Hengrui Medicine Co Ltd Hematologic Neoplasms; Neoplasms; Lymphoma Details
CC-90002 INBRX-103; CC-90002 Phase 1 Clinical Inhibrx Hematologic Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin Details

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