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Your Position: Home > CD47

CD47

Brief Information

Name:Cluster of differentiation 47
Target Synonym:MER6,CD47,Leukocyte surface antigen CD47,CD47 Molecule,Antigenic Surface Determinant Protein OA3,CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer),Antigen Identified By Monoclonal Antibody 1D8,Integrin Associated Protein,Rh-Related Antigen,CD47 Glycoprotein,IAP,Integrin-Associated Signal Transducer,Protein MER6,OA3,CD47 Antigen,Integrin-Associated Protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:36
Lastest Research Phase:Phase 3 Clinical

Licensing

Project item Indications Research phase Cooperation demands
BDA202202 Hematologic tumors, solid tumors License-out or co-development License-out or co-development

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Cat. No. Species Product Description Structure Purity Feature
MBS-K060 Human APC-labeled Human CD47-coupled Magnetic Beads
MBS-K059 Human PE-labeled Human CD47-coupled Magnetic Beads
EP-152 Human CD47 [Biotinylated] : SIRP alphaV2 Inhibitor Screening ELISA Kit
EP-138 Human CD47[Biotinylated] : SIRP alpha Inhibitor Screening ELISA Kit
MBS-K023 Human Human CD47-coupled Magnetic Beads
CD7-H82A3 Human Biotinylated Human CD47 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
CD7-H82A3-structure
CD7-H82A3-sds
CD7-HF2H3 Human FITC-Labeled Human CD47 Protein, His Tag
CD7-HF2H3-structure
CD7-HF2H3-sds
CD7-H82F8 Human Biotinylated Human CD47 Protein, Fc (L234A, L235A, P329G),Avitag™
CD7-H82F8-structure
CD7-H82F8-sds
CD7-M82E4 Mouse Biotinylated Mouse CD47 Protein, His,Avitag™
CD7-M82E4-structure
CD7-M82E4-sds
CD7-C52H5 Canine Canine CD47 Protein, His Tag
CD7-C52H5-structure
CD7-C52H5-sds
EP-102 Human CD47: SIRP alpha [Biotinylated] Inhibitor Screening ELISA Assay Pair
CD7-H522a Human Human CD47 Protein, His Tag, low endotoxin
CD7-H522a-structure
CD7-H522a-sds
CD7-H5251 Human Human CD47 Protein, Llama IgG2b Fc Tag, low endotoxin
CD7-H5251-structure
CD7-H5251-sds
CD7-M525a Mouse Mouse CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M525a-structure
CD7-M525a-sds
CD7-M522b Mouse Mouse CD47 Protein, His Tag (MALS verified)
CD7-M522b-structure
CD7-M522b-sds
CD7-C52H1 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD47 Protein, His Tag
CD7-C52H1-structure
CD7-C52H1-sds
CD7-HA2E9 Human Unconjugated Human CD47 Protein, His,Avitag™
CD7-HA2E9-structure
CD7-HA2E9-sds
CD7-H82E9 Human Biotinylated Human CD47 Protein, His,Avitag™
CD7-H82E9-structure
CD7-H82E9-sds
CD7-R5257 Rabbit Rabbit CD47 Protein, Fc Tag
CD7-R5257-structure
CD7-R5257-sds
CD7-R5256 Rat Rat CD47 Protein, Fc Tag
CD7-R5256-structure
CD7-R5256-sds
CD7-H52A5 Human Human CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H52A5-structure
CD7-H52A5-sds
CD7-C5252 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD47 Protein, Fc Tag
CD7-C5252-structure
CD7-C5252-sds
CD7-M5251 Mouse Mouse CD47 Protein, Fc Tag
CD7-M5251-structure
CD7-M5251-sds
CD7-H82F6 Human Biotinylated Human CD47 Protein, Fc,Avitag™
CD7-H82F6-structure
CD7-H82F6-sds
CD7-H5227 Human Human CD47 Protein, His Tag (MALS verified)
CD7-H5227-structure
CD7-H5227-sds
CD7-H5256 Human Human CD47 Protein, Fc Tag (MALS verified)
CD7-H5256-structure
CD7-H5256-sds
ACRO Quality

Part of Bioactivity data

CD7-H82E9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS assay shows that Biotinylated Human CD47, His,Avitag (Cat. No. CD7-H82E9) can bind to ACHN cell expressing human SIRP-a. The concentration of CD47 used is 10 μg/mL (Routinely tested).

Protocol
CD7-H82E9-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

FACS analysis shows that the binding of Human CD47 to ACHN expressing SIRP-a was inhibited by increasing concentration of neutralizing SIRP-a antibody. The concentration of Human CD47 used is 20 μg/mL. IC50=9.334 μg/mL

Protocol
CD7-C52H1-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-CD47 Mab (Human IgG4) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Cynomolgus/Rhesus macaque CD47, His Tag (Cat. No. CD7-C52H1) with an affinity constant of 1.8 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
CD7-H5227-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human CD47 MAb (Human IgG4) captured on CM5 chip via Anti-Human IgG Fc antibodies surface, can bind Human CD47, His Tag (Cat. No. CD7-H5227) with an affinity constant of 1.66 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

CD47,MER6,IAP,OA3

Background

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

Clinical and Translational Updates

Related Molecule

SIRP alpha

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SG404 SG-404; SG404 Phase 1 Clinical Hangzhou Sumgen Biotechnology Co Ltd Neoplasms Details
Anti-CD47 monoclonal antibody (Biocad) Phase 1 Clinical Biocad Neoplasms Details
IMM2505 IMM2505 Phase 1 Clinical Shenghe (China) Biopharmaceutical Co Ltd Solid tumours Details
JMT-601 JMT-601 Phase 1 Clinical Shanghai Jinmante Biological Technology Co Ltd Lymphoma, Non-Hodgkin Details
SG12473 SG12473; SG-12473 Phase 1 Clinical Hangzhou Sumgen Biotechnology Co Ltd Hematologic Neoplasms; Solid tumours; Neoplasms Details
Recombinant humanized anti-CD-47 monoclonal antibody (Shandong New Time Pharmaceutical) Phase 1 Clinical Shandong New Time Pharmaceutical Co Ltd Lymphoma Details
Kintuzumab(GenSci) Phase 1 Clinical Changchun Genescience Pharmaceutical Co Ltd Hematologic Neoplasms; Solid tumours; Lymphoma Details
CPO-107 Conjupro Biotherapeutics Inc Details
HX-009 HX-009 Phase 2 Clinical Hanx Biopharmaceutical Co Ltd, Wuhan Hanxiong Biotechnology Co Ltd Solid tumours; Liver Neoplasms; Stomach Neoplasms; Lymphoma Details
CC-90002 INBRX-103; CC-90002 Phase 1 Clinical Inhibrx Hematologic Neoplasms; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute Details
BAT-7104 BAT-7104 Phase 1 Clinical Bio-Thera Solutions Ltd Solid tumours; Neoplasms Details
SG-2501 SG-2501 Phase 1 Clinical Hangzhou Sumgen Biotechnology Co Ltd Hematologic Neoplasms; Lymphoma Details
TQB-2928 TQB-2928 Phase 1 Clinical Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd Hematologic Neoplasms; Solid tumours; Neoplasms Details
IMM-2902 IMM-2902 Phase 1 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Solid tumours; Stomach Neoplasms; Breast Neoplasms Details
NI-1801 NI-1801 Phase 1 Clinical Light Chain Bioscience Ltd Solid tumours; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
TG-1801 NI-1701; TG-1801 Phase 1 Clinical Novimmune Sa Lymphoma, B-Cell Details
PF-07257876 Phase 1 Clinical Pfizer Inc Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Non-Small-Cell Lung Details
Monoclonal Antibody (Mab) sB24M Phase 1 Clinical Swiss Biopharma Med GmbH Pyoderma Gangrenosum; Pyoderma Details
AL-008 AL-008; IBI-397 Phase 1 Clinical Alector Neoplasms Details
SL-172154 SL-172154 Phase 1 Clinical Shattuck Labs Inc Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Myelodysplastic Syndromes; Carcinoma, Ovarian Epithelial; Peritoneal Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms Details
SHS-009 SHS-009; SH009; SH-009 Phase 1 Clinical Nanjing Sanhome Pharmaceutical Co Ltd Neoplasms Details
Ligufalimab AK-117 Phase 2 Clinical Zhongshan Akeso Biopharma Co Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms; Neoplasms; Myelodysplastic Syndromes; Breast Neoplasms; Lymphoma; Leukemia, Myeloid, Acute Details
ZL-1201 ZL-1201 Phase 1 Clinical Zai Lab (Shanghai) Co Ltd Solid tumours; Hematologic Neoplasms; Neoplasms Details
Simridarlimab IBI-322; IBI322 Phase 1 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Bone Marrow Neoplasms; Hematologic Neoplasms; Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Lymphoma Details
Recombinant humanized monoclonal antibody MIL95(Mabworks/Connaught Biomedical Technology) MIL-95; CM-312 Phase 1 Clinical Beijing Mabworks Biotech Co Ltd, Keymed Biosciences Co Ltd Solid tumours; Neoplasms; Leukemia, Myeloid, Acute; Lymphoma Details
IMC-002(Immuneoncia) IMC-002; 3D-197; 3D197 Phase 1 Clinical Immuneoncia Therapeutics Inc Solid tumours; Hematologic Neoplasms; Neoplasms; Lymphoma; Neoplasm Metastasis Details
STI-6643 STI-6643 Phase 1 Clinical Sorrento Therapeutics Inc Solid tumours; Neoplasms Details
Evorpacept ALX148; ALX-148 Phase 3 Clinical Alexo Therapeutics Head and Neck Neoplasms; Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Myelodysplastic Syndromes; Neoplasms; Urinary Bladder Neoplasms; Colorectal Neoplasms; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Adenocarcinoma; Neoplasm Metastasis Details
Letaplimab IBI-188 Phase 3 Clinical Innovent Biologics(Suzhou) Co Ltd Solid tumours; Myeloproliferative Disorders; Neoplasms; Adenocarcinoma of Lung; Myelodysplastic Syndromes; Osteosarcoma; Leukemia, Myeloid, Acute Details
ISB-1442 ISB 1442; ISB-1442 Phase 2 Clinical Ichnos Sciences Sa Multiple Myeloma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute Details
PT-217 PT-217 Phase 1 Clinical Phanes Therapeutics Inc Small Cell Lung Carcinoma; Carcinoma, Neuroendocrine Details
6MW-3211 6MW3211; 6MW-3211 Phase 2 Clinical Mabwell (Shanghai) Bioscience Co Ltd Carcinoma, Renal Cell; Neoplasms; Myelodysplastic Syndromes; Lung Neoplasms; Lymphoma; Leukemia, Myeloid, Acute Details
Lemzoparlimab TJC-4; ABBV-IMAB-TJC4; TJ-1133; TJ-011133 Phase 3 Clinical I-Mab Biopharma Co Ltd, Abbvie Inc Hematologic Neoplasms; Solid tumours; Myelodysplastic Syndromes; Multiple Myeloma; Leukemia, Myeloid, Acute; Lymphoma Details
SG-1906 SG-1906; SG1906 Phase 1 Clinical Hangzhou Sumgen Biotechnology Co Ltd Neoplasms Details
Ontorpacept TTI-621 Phase 2 Clinical The Hospital For Sick Children, University Health Network, Trillium Therapeutics Inc Lymphoma, Follicular; Mycosis Fungoides; Melanoma; Carcinoma, Squamous Cell; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Sarcoma; Breast Neoplasms; Primary mediastinal B cell lymphoma; Lymphoma, B-Cell; Multiple Myeloma; Papillomavirus Infections; Skin Neoplasms; Lymphoma, Large B-Cell, Diffuse; Composite Lymphoma; Solid tumours; Hematologic Neoplasms; Leiomyosarcoma Details
IMM-2520 IMM-2520 Phase 1 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Solid tumours Details
BC-007 (Dragonboat Biopharmaceutical) BC-007 Phase 1 Clinical Dragonboat Biopharmaceutical Solid tumours; Neoplasms Details
AUR-103 AUR-103 Phase 1 Clinical Aurigene Leukemia; Solid tumours; Myelodysplastic Syndromes; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute Details
AUR-105 AUR-105 Phase 1 Clinical Aurigene Solid tumours; Hodgkin Disease; Lymphoma, Non-Hodgkin Details
IMM 01(ImmuneOnco Biopharma) IMM01; IMM 01 Phase 2 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Solid tumours; Leukemia, Promyelocytic, Acute; Myelodysplastic Syndromes; Hodgkin Disease; Multiple Myeloma; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma Details
IMM-0306 IMM-0306 Phase 2 Clinical ImmuneOnco Biopharmaceuticals (Shanghai) Co Ltd Lymphoma, B-Cell Details
HMPL-A83 HMPL-A-83; HMPL-A83 Phase 1 Clinical Solid tumours; Hematologic Neoplasms; Neoplasms Details
AO-176 AO-176; Ti-104; Ti-108; Ti-176 Phase 2 Clinical Arch Oncology Inc Solid tumours; Multiple Myeloma Details
TTI-622 TTI-622; PF-07901801 Phase 2 Clinical Trillium Therapeutics Inc Ovarian Neoplasms; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Ovarian Epithelial; Skin Neoplasms; Composite Lymphoma; Multiple Myeloma; Lymphoma, Follicular; Primary mediastinal B cell lymphoma; Peritoneal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma; Fallopian Tube Neoplasms; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell Details
PT-886 PT-886 Phase 1 Clinical Phanes Therapeutics Inc Stomach Neoplasms; Pancreatic Neoplasms Details
DSP-107 DSP-107; KAHR-107 Phase 2 Clinical Kahr Medical Solid tumours; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details
Magrolimab 5-F-9; Hu5F9-G4; ONO-7913 Phase 3 Clinical Stanford University Multiple Myeloma; Mycosis Fungoides; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Sezary Syndrome; Colorectal Neoplasms; Lymphoma, Mantle-Cell; Lymphoma, Follicular; Brain Neoplasms; Neuroblastoma; Osteosarcoma; Lymphoma, B-Cell; Myelodysplastic Syndromes; Triple Negative Breast Neoplasms; Hodgkin Disease; Squamous Cell Carcinoma of Head and Neck; Leukemia, Lymphoid; Ovarian Neoplasms; Leukemia, Myeloid; Hematologic Neoplasms; Solid tumours; Lymphoma, B-Cell, Marginal Zone Details
RRx-001 ABDNAZ; RRx-001 Phase 3 Clinical Epicentre Biotechnologies Llc Cholangiocarcinoma; Stomatitis; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Brain metastases; Carcinoma, Small Cell; Lymphoma; Colorectal Neoplasms; Brain Neoplasms; Solid tumours; Central Nervous System Neoplasms; Neuroendocrine Tumors; Oligodendroglioma; Neoplasms; Carcinoma, Ovarian Epithelial; Glioblastoma; Small Cell Lung Carcinoma Details

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