Netrin-1 Protein - ACROBiosystems

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Netrin-1

Brief Information

Name:Netrin 1
Target Synonym:Netrin-1,Netrin 1, Mouse, Homolog Of,MRMV4,Epididymis tissue protein Li 131P,NTN1L

Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical


NE1-H52H3	Human	Human Netrin-1 Protein, His Tag

Cat. No.

Species

Product Description

Structure

Purity

Feature

NE1-H52H3

Human

Human Netrin-1 Protein, His Tag

Part of Bioactivity data

NE1-H52H3-ELISA

Immobilized Human Netrin-1, His Tag (Cat. No. NE1-H52H3) at 5 μg/mL (100 μL/well) can bind Human Netrin receptor DCC, Fc Tag (Cat. No. NEC-H5254) with a linear range of 1-10 ng/mL (QC tested).

Protocol

Synonym Name

Netrin-1,NTN1,NTN1L,Netrin1,netrin 1

Background

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Clinical and Translational Updates

Clinical Drug Information