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Your Position: Home > Netrin-1

Netrin-1

Brief Information

Name:Netrin 1
Target Synonym:Netrin-1,Netrin 1, Mouse, Homolog Of,MRMV4,Epididymis tissue protein Li 131P,NTN1L
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
NE1-H52H3 Human Human Netrin-1 Protein, His Tag
NE1-H52H3-structure
NE1-H52H3-sds
ACRO Quality

Part of Bioactivity data

NE1-H52H3-ELISA
Netrin-1 ELISA

Immobilized Human Netrin-1, His Tag (Cat. No. NE1-H52H3) at 5 μg/mL (100 μL/well) can bind Human Netrin receptor DCC, Fc Tag (Cat. No. NEC-H5254) with a linear range of 1-10 ng/mL (QC tested).

Protocol

Synonym Name

Netrin-1,NTN1,NTN1L,Netrin1,netrin 1

Background

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NP-137 NP-137; NP-137R Phase 2 Clinical Centre Leon Berard, Netris Pharma Solid tumours; Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal; Endometrial Neoplasms; Carcinoma, Hepatocellular; Uterine Cervical Neoplasms Details

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