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Your Position: Home > LRRC15

LRRC15

Brief Information

Name:Leucine-rich repeat-containing protein 15
Target Synonym:LRRC15,Leucine-rich repeat-containing protein 15,hLib,Leucine Rich Repeat Containing 15,Leucine-Rich Repeat Protein Induced By Beta-Amyloid Homolog,LIB,Leucine-Rich Repeat Protein Induced By Beta Amyloid
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
LR5-C82F3 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque LRRC15 / LIB Protein, Fc,Avitag™ (MALS verified)
LR5-C82F3-structure
LR5-C82F3-sds
LR5-H51H3 Human Human LRRC15 / LIB Protein, His Tag (MALS verified)
LR5-H51H3-structure
LR5-H51H3-sds
LR5-M5253 Mouse Mouse LRRC15 / LIB Protein, Fc Tag (MALS verified)
LR5-M5253-structure
LR5-M5253-sds
MBS-K079 Human Human LRRC15-coupled Magnetic Beads
LR5-R82E3 Rat Biotinylated Rat LRRC15 / LIB Protein, His,Avitag™ (MALS verified)
LR5-R82E3-structure
LR5-R82E3-sds
LR5-C5253 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque LRRC15 / LIB Protein, Fc Tag (MALS verified)
LR5-C5253-structure
LR5-C5253-sds
LR5-C52H3 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque LRRC15 Protein, His Tag (MALS verified)
LR5-C52H3-structure
LR5-C52H3-sds
CHEK-ATP123 Human HEK293/Human LRRC15 Stable Cell Line
LR5-H82F9 Human Biotinylated Human LRRC15 / LIB Protein, Fc,Avitag™ (MALS verified)
LR5-H82F9-structure
LR5-H82F9-sds
LR5-H5257 Human Human LRRC15 / LIB Protein, Fc Tag (MALS verified)
LR5-H5257-structure
LR5-H5257-sds
LR5-C82E7 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque LRRC15 / LIB Protein, His,Avitag™
LR5-C82E7-structure
LR5-C82E7-sds
LR5-M82E6 Mouse Biotinylated Mouse LRRC15 / LIB Protein, His,Avitag™
LR5-M82E6-structure
LR5-M82E6-sds
LR5-M5225 Mouse Mouse LRRC15 / LIB Protein, His Tag (MALS verified)
LR5-M5225-structure
LR5-M5225-sds
LR5-H82E4 Human Biotinylated Human LRRC15 / LIB Protein, His,Avitag™ (MALS verified)
LR5-H82E4-structure
LR5-H82E4-sds
LR5-H52H3 Human Human LRRC15 / LIB Protein, His Tag (MALS verified)
LR5-H52H3-structure
LR5-H52H3-sds
ACRO Quality

Part of Bioactivity data

CHEK-ATP123-Cell-based assay
LRRC15 FACS

Expression analysis of human LRRC15 on HEK293/Human LRRC15 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human LRRC15 Stable Cell Line or negative control cell using anti-human LRRC15 antibody followed by staining with FITC anti-mouse IgG antibody.

Protocol
LR5-H51H3-SPR
LRRC15 SPR

Samrotamab captured on Protein A Chip can bind Human LRRC15 Protein, His Tag (Cat. No. LR5-H51H3) with an affinity constant of 22.3 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
LR5-H51H3-ELISA
LRRC15 ELISA

Immobilized Human LRRC15 Protein, His Tag (Cat. No. LR5-H51H3) at 2 μg/mL (100 μL/well) can bind Samrotamab with a linear range of 0.4-13 ng/mL (QC tested).

Protocol

Synonym Name

Leucine-rich repeat-containing protein 15,LRRC15,LIB,hLib

Background

LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.

Clinical and Translational Updates

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