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PTK7

Brief Information

Name:Protein-tyrosine kinase 7
Target Synonym:Colon carcinoma kinase 4,Inactive tyrosine-protein kinase 7,Tyrosine-protein kinase-like 7,CCK-4,PTK7,Protein Tyrosine Kinase 7 (Inactive),Pseudo Tyrosine Kinase Receptor 7,PTK7 Protein Tyrosine Kinase 7,CCK4,Protein-Tyrosine Kinase 7,Protein Tyrosine Kin
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Part of Bioactivity data

PT7-C52H3-MALS-HPLC
Cynomolgus / Rhesus macaque PTK7, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus / Rhesus macaque PTK7, His Tag (Cat. No. PT7-C52H3) was more than 85% and the molecular weight of this protein is around 80-116 kDa verified by SEC-MALS.

  • Background
    PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

    PT7-R52H4-MALS-HPLC
    Rabbit PTK7, His Tag (Cat. No. ) MALS images

    The purity of Rabbit PTK7, His Tag (Cat. No. PT7-R52H4) was more than 85% and the molecular weight of this protein is around 85-103 kDa verified by SEC-MALS.

Synonym Name

PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7

Background

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Cofetuzumab Pelidotin hu-24; PF-7020; PTK7-ADC; PF-6647020; PF-06523435; PF-06647020 Phase 1 Clinical Stemcentrx, Abbvie Inc Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details

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