FcRn (FCGRT & B2M) Overview
Molecule Name
IgG receptor FcRn large subunit p51
Synonyms
FcRn,FCGRT & B2M
Drug Development Progress
Drugs in Clinical Trials4
Approved Drugs4
Highest Development StageApproved
Target Synonym
Alpha-Chain，FcRn，Major Histocompatibility Complex Class I-Like Fc Receptor，Immunoglobulin Receptor， Intestinal， Heavy Chain，Neonatal Fc-Receptor For Ig，FcRn Alpha Chain，FCGRT，IgG Fc fragment receptor transporter alpha chain，Neonatal Fc receptor，Fc Fragment Of IgG Receptor And Transporter，Transmembrane Alpha Chain Of The Neonatal Receptor，Fc Fragment Of IgG， Receptor， Transporter， Alpha，IgG receptor FcRn large subunit p51，Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor
Background
FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
FcRn (FCGRT & B2M) Product List
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I***a2026-04-14I purchased rat fcrn from acrobio systems. It was a 25ug powder and I dissolved in my pbs buffer and aliquoted and kept in -20C. I used that fcrn to check the binding kinetics with human igg and assay was successful.FcRn was in high quality- N***i2024-12-24I recently used the Biotinylated Rabbit FcRn on the Biacore 8K+ and was highly impressed with its performance. The product worked perfectly as described, delivering reliable and consistent results. It also arrived within the expected time frame, which I greatly appreciated. Overall, I am very satisfied with the quality and service, and I would highly recommend this product to others
- C***n2023-05-03I used Acro's FcRn for development of novel assays. The proteins within just a few days of placing the order. The proteins were also high quality, stable, and did not result in any background in any of the assays that were developed, even after using them for months. These produced great data and we have continued to repurchase them since. I would highly recommend this product.