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Fig. FACS analysis of FcRn (FCGRT & B2M) on HEK293/FcRn (FCGRT & B2M), GFP Tag Stable Cell Line.
HEK293/FcRn (FCGRT & B2M), GFP Tag Stable Cell Line was red line, negative control HEK293 cells was grey line(QC tested).
FACS analysis of FcRn (FCGRT & B2M) on HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line.
FACS assay shows that FITC-Labeled Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) Protein, His Tag (Cat. No. IG1-HF2H3) can bind to HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line. HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line was red line, negative control HEK293 cells was grey line(QC tested).
Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F), His Tag (Cat. No. IG1-H52H8) immobilized on CM4 Chip can bind Human FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (Cat. No. FCM-H5283) with an affinity constant of 23.8 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
---|---|---|---|---|---|---|---|---|---|---|
Efgartigimod alfa | ARGX-113; EFG PH20; EFG PH20 SC; PH20 SC | Approved | Argenx Se | VYVGART HYTRULO, Vyvgart, 卫伟迦, VYVGART | United States | Myasthenia Gravis | Argenx BV | 2021-12-17 | Postural Orthostatic Tachycardia Syndrome; Tachycardia; Pemphigus; Nephrotic Syndrome; Muscular Diseases; Guillain-Barre Syndrome; Thrombocytopenia; Pemphigoid, Bullous; Glomerulonephritis, Membranous; Graves Ophthalmopathy; Lupus Nephritis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome; Autoimmune Diseases; Polyneuropathies; Nephrosis; Dermatomyositis; Myositis; Polymyositis; Myasthenia Gravis; Purpura, Thrombocytopenic, Idiopathic | Details |
Rozanolixizumab | UCB-7665 | Approved | Ucb Sa | RYSTIGGO | United States | Myasthenia Gravis | Ucb Inc | 2023-06-27 | Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic; Myasthenia Gravis; Thrombocytopenia; Glioma; Fibromyalgia; Encephalitis | Details |
Efgartigimod alfa/Hyaluronidase | Approved | Argenx BV | VYVDURA, VYVGART HYTRULO | United States | Myasthenia Gravis | Argenx BV | 2023-06-20 | Myasthenia Gravis | Details | |
Efgartigimod alfa | ARGX-113; EFG PH20; EFG PH20 SC; PH20 SC | Approved | Argenx Se | VYVGART HYTRULO, Vyvgart, 卫伟迦, VYVGART | United States | Myasthenia Gravis | Argenx BV | 2021-12-17 | Postural Orthostatic Tachycardia Syndrome; Tachycardia; Pemphigus; Nephrotic Syndrome; Muscular Diseases; Guillain-Barre Syndrome; Thrombocytopenia; Pemphigoid, Bullous; Glomerulonephritis, Membranous; Graves Ophthalmopathy; Lupus Nephritis; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Sjogren's Syndrome; Autoimmune Diseases; Polyneuropathies; Nephrosis; Dermatomyositis; Myositis; Polymyositis; Myasthenia Gravis; Purpura, Thrombocytopenic, Idiopathic | Details |
Rozanolixizumab | UCB-7665 | Approved | Ucb Sa | RYSTIGGO | United States | Myasthenia Gravis | Ucb Inc | 2023-06-27 | Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Purpura, Thrombocytopenic, Idiopathic; Myasthenia Gravis; Thrombocytopenia; Glioma; Fibromyalgia; Encephalitis | Details |
Efgartigimod alfa/Hyaluronidase | Approved | Argenx BV | VYVDURA, VYVGART HYTRULO | United States | Myasthenia Gravis | Argenx BV | 2023-06-20 | Myasthenia Gravis | Details |
Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
Nipocalimab | M-281; JNJ-80202135 | Phase 3 Clinical | Momenta | Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Myasthenia Gravis; Hemolysis; Myositis; Arthritis, Rheumatoid; Sjogren's Syndrome; Lupus Nephritis; Anemia, Hemolytic, Autoimmune; Lupus Erythematosus, Systemic; Pemphigoid, Bullous | Details |
IMVT-1402 | HL-161 ANS; IMVT-1402 | Phase 1 Clinical | Immunovant Sciences Gmbh, HanAll Biopharma Co Ltd | Autoimmune Diseases | Details |
Nipocalimab | M-281; JNJ-80202135 | Phase 3 Clinical | Momenta | Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Myasthenia Gravis; Hemolysis; Myositis; Arthritis, Rheumatoid; Sjogren's Syndrome; Lupus Nephritis; Anemia, Hemolytic, Autoimmune; Lupus Erythematosus, Systemic; Pemphigoid, Bullous | Details |
IMVT-1402 | HL-161 ANS; IMVT-1402 | Phase 1 Clinical | Immunovant Sciences Gmbh, HanAll Biopharma Co Ltd | Autoimmune Diseases | Details |
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