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ROR2

Brief Information

Name:Tyrosine-protein kinase transmembrane receptor ROR2
Target Synonym:EC:2.7.10.1,ROR2,NTRKR2,Receptor Tyrosine Kinase Like Orphan Receptor 2,Tyrosine-Protein Kinase Transmembrane Receptor ROR2,Neurotrophic Tyrosine Kinase, Receptor-Related 2,Neurotrophic Tyrosine Kinase Receptor-Related 2,Receptor Tyrosine Kinase-Like Orph
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

RO2-H52E5-ELISA
Human ROR2, His TagHuman ROR2, His Tag (Cat. No. RO2-H52E5) ELISA bioactivity

Immobilized Human ROR2, His Tag (Cat. No. RO2-H52E5) at 1 μg/mL (100 μL/well) can bind Anti-ROR2 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

RO2-H82E3-ELISA
Biotinylated Human ROR2, His,AvitagBiotinylated Human ROR2, His,Avitag (Cat. No. RO2-H82E3) ELISA bioactivity

Immobilized Biotinylated Human ROR2, His,Avitag (Cat. No. RO2-H82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-ROR2 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

Synonym Name

ROR2,NTRKR2

Background

Tyrosine-protein kinase transmembrane receptor ROR2 is also known as Neurotrophic tyrosine kinase, receptor-related 2 (NTRKR2), which belongs to the protein kinase superfamily and Tyr protein kinase family and ROR subfamily. ROR2 is a homodimer protein, which can binds YWHAB or interact with WTIP. ROR2 may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
BA-3021 BA-3021; CAB-ADC; CAB-ROR2; CAB-ROR2-ADC Phase 2 Clinical Bioatla Triple Negative Breast Neoplasms; Sarcoma; Carcinoma, Non-Small-Cell Lung Details

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