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Your Position: Home > Integrin alpha V beta 1

Integrin alpha V beta 1

Brief Information

Name:Integrin alpha-V/beta-1
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IT1-H5213 Human Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, Tag Free&Tag Free
IT1-H5213-structure
IT1-H5213-sds
IT1-H82W6 Human Biotinylated Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His,Avitag™&Tag Free
IT1-H82W6-structure
IT1-H82W6-sds
IT1-H52E1 Human Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, His Tag&Tag Free
IT1-H52E1-structure
IT1-H52E1-sds
ACRO Quality

Part of Bioactivity data

IT1-H82W6-ELISA
Biotinylated Human ITGAV&ITGB1 Heterodimer Protein, His,Avitag&Tag FreeBiotinylated Human ITGAV&ITGB1 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT1-H82W6) ELISA bioactivity

Immobilized Fibronectin at 5 μg/mL (100 μL/well) can bind Biotinylated Human ITGAV&ITGB1 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT1-H82W6) with a linear range of 0.039-0.625 μg/mL (QC tested).

Protocol
IT1-H5213-ELISA
Human ITGAV&ITGB1 Heterodimer Protein, Tag Free&Tag FreeHuman ITGAV&ITGB1 Heterodimer Protein, Tag Free&Tag Free (Cat. No. IT1-H5213) ELISA bioactivity

Immobilized Recombinant Human Fibronectin at 2 μg/mL (100 μL/well) can bind Human ITGAV&ITGB1 Heterodimer Protein, Tag Free&Tag Free (Cat. No. IT1-H5213) with a linear range of 0.002-0.313 μg/mL (QC tested).

Protocol

Synonym Name

Integrin alpha V beta 1,ITGAV&ITGB1

Background

Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PLN-1474 PLN-1474 Phase 1 Clinical Pliant Therapeutics Inc, Novartis Pharma Ag Non-alcoholic Fatty Liver Disease; Liver Cirrhosis Details
IDL-2965 IDL-2965 Phase 2 Clinical Indalo Therapeutics Inc Non-alcoholic Fatty Liver Disease; Idiopathic Pulmonary Fibrosis Details
PLN-74809 PLN-74809 Phase 2 Clinical Pliant Therapeutics Inc Idiopathic Pulmonary Fibrosis; Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult; Cholangitis, Sclerosing Details

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