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Your Position: Home > Integrin isoform alpha-7X2B beta 1

Integrin isoform alpha-7X2B beta 1

Brief Information

Name:Integrin alpha7/beta1
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
IT1-H82W5 Human Biotinylated Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, Avitag™&His,Avitag™
IT1-H82W5-structure
IT1-H82W5-sds
IT1-H52W8 Human Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein, His Tag&Tag Free
IT1-H52W8-structure
IT1-H52W8-sds
ACRO Quality

Part of Bioactivity data

IT1-H52W8-BLI
Integrin isoform alpha-7X2B beta 1 ELISA

Immobilized Human ITGA7X2B&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52W8) at 5 μg/mL (100 μL/well) can bind Human Laminin 221 Protein, premium grade (Cat. No. LA2-H5269) with a linear range of 0.2-5 ng/mL (QC tested).

Protocol

Synonym Name

Integrin isoform alpha-7X2B beta 1,ITGA7X2BB1,ITGA7X2B&ITGB1

Background

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.

Clinical and Translational Updates

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