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CBLB

CBLB Overview

English NameE3 ubiquitin-protein ligase CBL-BApproved Drugs0
Drugs in Clinical Trials3Target SynonymCas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B，Casitas B-lineage lymphoma proto-oncogene b，RING-type E3 ubiquitin transferase CBL-B，SH3-binding protein CBL-B，RING finger protein 56，Nbla00127，RNF56，Signal transduction protein CBL-B，Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B，Cbl Proto-Oncogene， E3 Ubiquitin Protein Ligase B，Cbl Proto-Oncogene B，Cbl Proto-Oncogene B， E3 Ubiquitin Protein Ligase，Cbl-B
Highest Development StagePhase 2 Clinical
English NameE3 ubiquitin-protein ligase CBL-B
Target SynonymCas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B，Casitas B-lineage lymphoma proto-oncogene b，RING-type E3 ubiquitin transferase CBL-B，SH3-binding protein CBL-B，RING finger protein 56，Nbla00127，RNF56，Signal transduction protein CBL-B，Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence B，Cbl Proto-Oncogene， E3 Ubiquitin Protein Ligase B，Cbl Proto-Oncogene B，Cbl Proto-Oncogene B， E3 Ubiquitin Protein Ligase，Cbl-B
Approved Drugs0
Drugs in Clinical Trials3
Highest Development StagePhase 2 Clinical

CBLB Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
CBB-H5148
Human
E. coli
Human CBLB / RNF56 Protein, His Tag
Total: 1
  • 1

CBLB Background

Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.

CBLB Synonyms

CBL-B,CBLB,RNF56

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
HST-1011HST-1011; HST1011Phase 2 ClinicalHotSpot Therapeutics IncNeoplasms; Solid tumours
Details
APN-401APN-401Phase 1 ClinicalApeiron BiologicsBrain metastases; Carcinoma, Renal Cell; Colorectal Neoplasms; Melanoma; Neoplasm Metastasis; Pancreatic Neoplasms; Solid tumours
Details
NX-1607NX-1607Phase 1 ClinicalNurix Therapeutics IncCarcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Colorectal Neoplasms; Esophageal Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mesothelioma; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Richter's Syndrome; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms
Details
  • Overview
  • Product List
  • Clinical Drug Information
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