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Your Position: Home > DLL3

DLL3

Brief Information

Name:Delta-like protein 3
Target Synonym:Delta-Like Protein 3,Delta3,Delta-Like 3,Drosophila Delta Homolog 3,SCDO1,Delta-Like 3 (Drosophila),DLL3,Delta (Drosophila)-Like 3,Delta Like Canonical Notch Ligand 3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

DL3-H52Hz-ELISA
Human DLL3 (312-492) , His TagHuman DLL3 (312-492) , His Tag (Cat. No. DL3-H52Hz) ELISA bioactivity

Immobilized Human DLL3 (312-492) , His Tag (Cat. No. DL3-H52Hz) at 1 μg/mL (100 μL/well) can bind Anti-DLL3 Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL (QC tested).

DL3-H82E4-MALS-HPLC
Biotinylated Human DLL3, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human DLL3, His,Avitag (Cat. No. DL3-H82E4) is more than 90% and the molecular weight of this protein is around 51-69 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human DLL3, His,AvitagBiotinylated Human DLL3, His,Avitag (Cat. No. DL3-H82E4) ELISA bioactivity

Immobilized Biotinylated Human DLL3, His,Avitag (Cat. No. DL3-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-DLL3 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

Synonym Name

Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
89Zr-DFO-SC16.56 89Zr-DFO-SC16.56 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Small Cell Lung Carcinoma Details
HPN-328 HPN-328 Phase 2 Clinical Harpoon Therapeutics Small Cell Lung Carcinoma Details
Tarlatamab AMG-757 Phase 2 Clinical Amgen Inc Small Cell Lung Carcinoma; Prostatic Neoplasms Details
Rovalpituzumab tesirine SC0001SCX; SC16LD6.5; SC0001-SCX; SC-0002; P256HB60FF Phase 1 Clinical Abbvie Inc, Stemcentrx Solid tumours; Small Cell Lung Carcinoma; Glioblastoma; Medullary thyroid cancer (MTC); Prostatic Neoplasms; Carcinoma, Neuroendocrine; Melanoma Details

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