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Your Position: Home > DLL3

DLL3

Brief Information

Name:Delta-like protein 3
Target Synonym:Delta-Like Protein 3,Delta3,Delta-Like 3,Drosophila Delta Homolog 3,SCDO1,Delta-Like 3 (Drosophila),DLL3,Delta (Drosophila)-Like 3,Delta Like Canonical Notch Ligand 3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

DL3-C52H9-ELISA
Cynomolgus DLL3 (27-488), His TagCynomolgus DLL3 (27-488), His Tag (Cat. No. DL3-C52H9) ELISA bioactivity

Immobilized Cynomolgus DLL3 (27-488), His Tag (Cat. No. DL3-C52H9) at 1 μg/mL (100 μL/well) can bind Anti-DLL3 Antibody (specific Binding DSL of DLL3), Human IgG1 with a linear range of 0.1-3 ng/mL (QC tested).

DL3-H525b-MALS-HPLC
DLL3 MALS images

The purity of Human DLL3, Llama IgG2b Fc Tag, low endotoxin(Cat. No. DL3-H525b) is more than 90% and the molecular weight of this protein is around 95-115 kDa verified by SEC-MALS.

Synonym Name

Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
89Zr-DFO-SC16.56 89Zr-DFO-SC16.56 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Small Cell Lung Carcinoma Details
AMG-119 AMG-119 Amgen Inc Details
HPN-328 HPN-328 Harpoon Therapeutics Details
QLS-31904 QLS31904; QLS-31904 Phase 1 Clinical Qilu Pharmaceutical Co Ltd Solid tumours Details
Tarlatamab AMG-757 Phase 2 Clinical Amgen Inc Small Cell Lung Carcinoma; Prostatic Neoplasms Details

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