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DLL3

Brief Information

Name:Delta-like protein 3
Target Synonym:DLL3,Delta (Drosophila)-Like 3,Delta Like Canonical Notch Ligand 3,Delta3,Drosophila Delta Homolog 3,Delta-Like 3,Delta-Like Protein 3,SCDO1,Delta-Like 3 (Drosophila)
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:5
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

DL3-HF253-ELISA
FITC-Labeled Human DLL3, Fc TagFITC-Labeled Human DLL3, Fc Tag (Cat. No. DL3-HF253) ELISA bioactivity

Immobilized Anti-DLL3 Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind FITC-Labeled Human DLL3, Fc Tag (Cat. No. DL3-HF253) with a linear range of 0.01-0.313 μg/mL (QC tested).

DL3-H52H4-MALS-HPLC
Human DLL3, His Tag (Cat. No. ) MALS images

The purity of Human DLL3, His Tag(Cat. No. DL3-H52H4) was more than 95% and the molecular weight of this protein is around 55-75 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human DLL3, His TagHuman DLL3, His Tag (Cat. No. DL3-H52H4) ELISA bioactivity

Immobilized Human DLL3, His Tag (Cat. No. DL3-H52H4) at 1 μg/mL (100 μL/well) can bind Anti-DLL3 Antibody, Human IgG1 with a linear range of 0.2-2 ng/mL (QC tested).

Synonym Name

Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
89Zr-DFO-SC16.56 89Zr-DFO-SC16.56 Phase 1 Clinical Memorial Sloan Kettering Cancer Center Small Cell Lung Carcinoma Details
Rovalpituzumab tesirine SC-0002; SC0001SCX; SC16LD6.5; SC0001-SCX; P256HB60FF Phase 3 Clinical Stemcentrx, Abbvie Inc Solid tumours; Small Cell Lung Carcinoma; Glioblastoma; Medullary thyroid cancer (MTC); Prostatic Neoplasms; Carcinoma, Neuroendocrine; Melanoma Details
HPN-328 HPN-328 Phase 2 Clinical Harpoon Therapeutics Small Cell Lung Carcinoma Details
Tarlatamab AMG-757 Phase 1 Clinical Amgen Inc Small Cell Lung Carcinoma; Prostatic Neoplasms Details

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