LRP-6 Protein - ACROBiosystems

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LRP-6


LR6-H5253	Human	Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag

Cat. No.

Species

Product Description

Structure

Purity

Feature

LR6-H5253

Human

Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag

Part of Bioactivity data

LR6-H5253-SPR

Human LRP-6 (20-630), Mouse IgG2a Fc TagHuman LRP-6 (20-630), Mouse IgG2a Fc Tag (Cat. No. LR6-H5253) ELISA bioactivity

Immobilized Mouse Dkk-1, His Tag (Cat. No. DK1-M52H6) at 5 μg/mL (100 μL/well) can bind Human LRP-6 (20-630), Mouse IgG2a Fc Tag (Cat. No. LR6-H5253) with a linear range of 10-78 ng/mL (QC tested).

Protocol

Synonym Name

LRP-6,LRP6

Background

LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

Clinical and Translational Updates