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Your Position: Home > LRP-5

LRP-5

Brief Information

Name:Low-density lipoprotein receptor-related protein 5
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
LR5-H82E6 Human Biotinylated Human LRP-5 Protein, His,Avitag™
LR5-H82E6-structure
LR5-H82E6-sds
LR5-H5254 Human Human LRP-5 Protein, Mouse IgG2a Fc Tag
LR5-H5254-structure
LR5-H5254-sds
ACRO Quality

Part of Bioactivity data

LR5-H5254-ELISA
LRP-5 ELISA

Immobilized Biotinylated Human Dkk-1, Fc,Avitag (Cat. No. DK1-H82F5) at 5 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human LRP-5, Mouse IgG2a Fc Tag (Cat. No. LR5-H5254) with a linear range of 1-31 ng/mL (QC tested).

Protocol

Synonym Name

LRP5,LRP-5,LRP-7,LRP7,LR3

Background

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as  BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Restoret EYE103; EYE-103; MK-3000; ANT-39 Phase 3 Clinical Eyebiotech Ltd Diabetic macular oedema; Macular Degeneration Details
BI-905681 BI-905681 Phase 1 Clinical Boehringer Ingelheim Ltd Neoplasms Details

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