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Integrin alpha 10 beta 1

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Part of Bioactivity data

IT1-H52Wa-ELISA
Human ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag FreeHuman ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wa) ELISA bioactivity

Immobilized Human Collagen I protein at 2 μg/mL (100 μL/well) can bind Human ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-H52Wa) with a linear range of 0.02-0.313 μg/mL (QC tested).

IT1-M52W4-ELISA
Mouse ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag FreeMouse ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W4) ELISA bioactivity

Immobilized Human Collagen IV at 2 μg/mL (100 μL/well) can bind Mouse ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-M52W4) with a linear range of 0.039-1.25 μg/mL (QC tested).

Synonym Name

Integrin alpha 10 beta 1,ITGA10&ITGB1

Background

Human integrin alpha(10)I domain as a recombinant protein to reveal its ligand binding specificity. In general, alpha(10)I did recognize collagen types I-VI and laminin-1 in a Mg(2+)-dependent manner, whereas its binding to tenascin was only slightly better than to albumin. Alpha 10 beta 1 is a known collagen-binding I domain integrin, in addition to α1β1, α2β1 and α11β1. GROGER found in the N-terminal domain of collagens I and III, is only weakly recognised by α10β1, an important collagen receptor on chondrocytes, contrasting with the other collagen-binding integrins.

Clinical and Translational Updates

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