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Your Position: Home > Receptor Tyrosine Kinases > ErbB3 > ER3-H5288

Human ErbB3 / Her3 Protein, Strep Tag

INTRODUCTION

QC & Assay Protocol

Citation & Background

Synonym
ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3
Source
Human ErbB3, Strep Tag (ER3-H5288) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # NP_001973.2).
Predicted N-terminus: Ser 20
Request for sequence
Molecular Characterization
This protein carries a twin strep tag at the C-terminus.
The protein has a calculated MW of 71.7 kDa. The protein migrates as 100-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method.
Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20^°C to -70^°C for 12 months in lyophilized state;
2. -70^°C for 3 months under sterile conditions after reconstitution.

SDS-PAGE

Human ErbB3, Strep Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA

Human ErbB3, Strep TagHuman ErbB3, Strep Tag (Cat. No. ER3-H5288) ELISA bioactivity

Immobilized Human ErbB3, Strep Tag (Cat. No. ER3-H5288) at 2 μg/mL (100 μL/well) can bind Human NRG1-beta 1 Protein with a linear range of 1-10 ng/mL (Routinely tested).

Protocol

Background
ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
References
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Order Details

ER3-H5288-25ug

Price(USD) : $260.00

ER3-H5288-250ug

Price(USD) : $880.00

ER3-H5288-1mg (250ug × 4)

Price(USD) : $2300.00

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English Name	Research Code	Research Phase	Company	Indications	Clinical Trials
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AC-480	AC-480; BMS-599626 ,AC480; BMS599626 ,AC 480; BMS 599626	Phase Ⅰ	Ambit biosciences	Glioma, Solid tumours	Details
Patritumab	AMG-888; U3-1287,AMG888,U31287	Phase Ⅲ	Daiichi Sankyo, Amgen	Non small cell lung cancer (NSCLC), Metastatic breast cancer	Details
SPC-3920	SPC-3920; EZN-3920	Preclinical	Roche	Cancer	Details
Seribantumab	MM-121; SAR-256212; 1N3L70MDFX (UNII code)	Phase Ⅱ	Merrimack, Sanofi	Non small cell lung cancer (NSCLC), Breast cancer, Solid tumours, Ovarian cancer	Details
Sapitinib	AZD-8931	Phase Ⅱ	AstraZeneca	Colorectal cancer	Details
ISU-104	ISU-104	Phase Ⅰ	ISU Abxis	Solid tumours	Details
REGN-1400	REGN-1400	Phase Ⅰ	Regeneron Pharmaceutical	Solid tumours	Details
GSK-2849330	GSK-2849330,GSK2849330	Phase Ⅰ	GlaxoSmithKline	Solid tumours	Details
Recombinant human ErbB3 fragment vaccine (Zensun)	rhErbB3-f	Phase Ⅰ	Zensun	Solid tumours	Details
Tesevatinib	EXEL-7647; KD-019; KD-020; XL-647,KD019,EXEL7647,KD020,XL647	Phase Ⅲ	Exelixis, Kadmon	Non small cell lung cancer (NSCLC), Autosomal dominant polycystic kidney disease (ADPKD)	Details
MP-0274	CME-114; SPA-28; MP-0274; CME-119; CME-118; CME-115; DARPin-41	Phase Ⅰ	Molecular Partners	Solid tumours	Details
Elisidepsin	PM-02734; PM-2734	Phase Ⅱ	PharmaMar	Solid tumours	Details
Recombinat humanized HER3-targeting antibody		Phase Ⅰ	Shanghai Institute of Biological Products	Solid tumours	Details
Sirotinib Maleate	XZP-5491,XZP5491	Phase Ⅰ	XuanZhu Pharma	Esophageal squamous cell carcinoma, Non small cell lung cancer (NSCLC), Gastric cancer	Details
Sym-013	Sym-013,Sym 013,Sym013	Phase Ⅱ	Symphogen	Cancer	Details
U3-1402	U3-1402,U31402; U3 1402	Phase Ⅱ	Daiichi Sankyo	Non small cell lung cancer (NSCLC), Breast cancer	Details
Duligotuzumab (Genentech)	MEHD-7945A; RG-7597; RO-5541078,MEHD7945A; RG7597; RO5541078	Phase Ⅰ	Genentech	Solid tumours	Details
HMBD-001	HMBD-001,MBD-001-10D1	Preclinical	Hummingbird Bioscience	Solid tumours	Details
MM-111	MM-111	Phase Ⅱ	Merrimack	Gastric cancer, Esophagus cancer, Breast cancer, Solid tumours	Details
Zenocutuzumab	MCLA-128	Phase Ⅱ	Merus	Non small cell lung cancer (NSCLC), Gastric cancer, Solid tumours, Metastatic breast cancer, Ovarian cancer	Details
Lumretuzumab	RG-7116; RO-5479599	Phase Ⅱ	Roche	Non small cell lung cancer (NSCLC), Breast cancer, Solid tumours	Details
Elgemtumab	LJM-716; NOV-6	Phase Ⅱ	MorphoSys, Novartis	Gastric cancer, Esophagus cancer, Breast cancer, Solid tumours, Head and neck cancer	Details
TAD011	TAD-011,TAD011; TAD 011	IND Filing	TOT Biopharm	Brain cancer, Colorectal cancer, Head and neck cancer, Pancreatic cancer	Details
AV-203	AV-203; CAN-017,CAN017	Phase Ⅰ	AVEO, CANbridge Life Sciences	Solid tumours	Details
Istiratumab	MM-141; XLR461MD3M (UNII code)	Phase Ⅱ	Merrimack, Shire, Adimab	Ovarian cancer, Pancreatic cancer	Details
SI-B001	SI-B001	Phase Ⅰ	Sichuan Baili Pharmaceutical	Cancer	Details