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Your Position: Home > Protein > CTLA-4 > CT4-R5250

Rabbit CTLA-4 / CD152 Protein, Fc Tag

  • Synonym
  • Source
    Rabbit CTLA-4, Fc Tag (CT4-R5250) is expressed from human 293 cells (HEK293). It contains AA Lys 36 - Asp 161 (Accession # P42072).
    Predicted N-terminus: Lys 36
  • Molecular Characterization
    Online(Lys 36 - Asp 161) P42072

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 40.3 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Rabbit CTLA-4, Fc Tag (Cat. No. CT4-R5250) SDS-PAGE gel

Rabbit CTLA-4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

Rabbit CTLA-4, Fc TagRabbit CTLA-4, Fc Tag (Cat. No. CT4-R5250) ELISA bioactivity

Immobilized Human B7-1, mouse IgG2a Fc Tag, low endotoxin (Cat. No. B71-H52A4) at 5 μg/mL (100 μL/well)can bind Rabbit CTLA-4, Fc Tag (Cat. No. CT4-R5250) with a linear range of 0.1-0.8 ng/mL (QC tested).

Rabbit CTLA-4, Fc TagRabbit CTLA-4, Fc Tag (Cat. No. CT4-R5250) ELISA bioactivity

Immobilized Human B7-2, His Tag (Cat. No. CD6-H5223) at 5 μg/mL (100 μL/well)can bind Rabbit CTLA-4, Fc Tag (Cat. No. CT4-R5250) with a linear range of 5-78 ng/mL (Routinely tested).

  • Background
    CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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