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Your Position: Home > Receptor Tyrosine Kinases > BMPR-IA > Human ALK-3/BMPR1A Protein,with Fc Tag

Human BMPR-IA / ALK-3 Protein, Fc Tag

  • Synonym
    BMPR-1A,ALK-3,10q23del,ACVRLK3,CD292,SKR5
  • Source
    Human BMPR-IA, Fc Tag (AL3-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Arg 152 (Accession # CAA80257).
    Predicted N-terminus: Gln 24
  • Molecular Characterization
    BMPR-IA(Gln 24 - Arg 152) CAA80257

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 42 kDa. The protein migrates as 56 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >98% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human BMPR-IA, Fc Tag (Cat. No. AL3-H5259) SDS-PAGE gel

Human BMPR-IA, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.

  • Background
    The bone morphogenetic protein receptor, type IA is also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2[1]. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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