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Your Position: Home > Cytokines > IL-17A > ILA-C5249

Cynomolgus IL-17A / CTLA-8 Protein, His Tag

  • Synonym
    IL-17A,Interleukin-17A,CTLA-8,IL-17
  • Source
    Cynomolgus IL-17A, His Tag (ILA-C5249) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Ala 155 (Accession # G7P4U9-1).
    Predicted N-terminus: His
  • Molecular Characterization
    Online(Gly 24 - Ala 155) G7P4U9-1

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 17.0 kDa. The protein migrates as 18-19 kDa,24-25 kDa and 28-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus IL-17A, His Tag (Cat. No. ILA-C5249) SDS-PAGE gel

Cynomolgus IL-17A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Cynomolgus IL-17A, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus IL-17A, His Tag (Cat. No. ILA-C5249) was more than 90% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

Bioactivity-ELISA
Cynomolgus IL-17A, His TagCynomolgus IL-17A, His Tag (Cat. No. ILA-C5249) ELISA bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus IL-17A, His Tag (Cat. No. ILA-C5249) at 2 μg/mL (100 μL/well) can bind Human IL-17 RA, Fc Tag (MALS verified) (Cat. No. ILA-H5257) with a linear range of 0.2-3 ng/mL (QC tested).

Cynomolgus IL-17A, His TagCynomolgus IL-17A, His Tag (Cat. No. ILA-C5249) ELISA bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus IL-17A, His Tag (Cat. No. ILA-C5249) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human IL17A Antibody, Human IgG1 with a linear range of 0.1-0.8 ng/mL (Routinely tested).

Cynomolgus IL-17A, His TagCynomolgus IL-17A, His Tag (Cat. No. ILA-C5249) ELISA bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus IL-17A, His Tag (Cat. No. ILA-C5249) at 2 μg/mL (100 μL/well) can bind Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with a linear range of 10-80 ng/mL (Routinely tested).

  • Background
    Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $380.00

Price(USD) : $2540.00

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  • Latest Research Phase:Approved

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